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Overview

Uniprot ID	A0A286ZIV9
Protein Name	Pre-mRNA-processing factor 40 homolog A
Gene Name	PRPF40A
Organism	Sus scrofa

Kla Sites from experimental identification

Position	Flanking peptide
225	LLSKCPWKEYKSDSG

Function

Binds to WASL/N-WASP and suppresses its translocation from the nucleus to the cytoplasm, thereby inhibiting its cytoplasmic function. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. May play a role in cytokinesis. May be involved in pre-mRNA splicing

Protein Sequence

10 MQATPSEAEV 20 GSESPKSCVS 30 AAQSDWTAEK 40 PVSLLAPLVP 50 PRSAGQPLTF 60 GPSGLQPLRS 70 LLVGMCSGSG 80 RRRSSLSPTM 90 RPGTGAERGG 100 LMMGHPSMHY 110 APMGMHPMGQ 120 RANMPPVPHG 130 MMPQMMPPMG 140 GPPMGQMPGM 150 MSSVMPGMMM 160 SHMSQASMQP 170 ALPPGVNNMD 180 VAAGATSGAK 190 SMWTEHKSPD 200 GRTYYYNTET 210 KQSTWEKPDD 220 LKTPAEQLLS 230 KCPWKEYKSD 240 SGKPYYYNSQ 250 TKESRWAKPK 260 ELEDLEGYQN 270 TIVAGSLITK 280 SNLHAMIKAE 290 ESSKQEECTT 300 TSAAPVPTTE 310 IPTTMSTMAA 320 AEAAAAVVAA 330 AAAAAAAAAA 340 ANASASTSAS 350 STVGGTVPVV 360 PEPEDQSVEV 370 SSNTGEETSK 380 QEAVADFTPK 390 KEEEENQPAK 400 KTYTWNTKEE 410 AKQAFKELLK 420 EKRVPSNASW 430 EQAMKMIIND 440 PRYSALAKLS 450 EKKQAFNAYK 460 VQTEKEEKEE 470 ARSKYKEAKE 480 SFQRFLENHE 490 KMTSTTRYKK 500 AEQMFGEMEV 510 WNAISERDRL 520 EIYEDVLFFL 530 SKKEKEQAKQ 540 LRKRNWEALK 550 NILDNMANVT 560 YSTTWSEAQQ 570 YLMDNPTFAE 580 DEELQNMDKE 590 DALICFEEHI 600 RALEKEEEEE 610 KQKSLLRERR 620 RQRKNRESFQ 630 IFLDELHEHG 640 QLHSMSSWME 650 LYPTISSDIR 660 FTNMLGQPGS 670 TALDLFKFYV 680 EDLKARYHDE 690 KKIIKDILKD 700 KGFVVEVNTT 710 FEDFVAIISS 720 TKRSTTLDAG 730 NIKLAFNSLL 740 EKAEARERER 750 EKEEARKMKR 760 KESAFKSMLK 770 QATPPIELDA 780 VWEDIRERFV 790 KEPAFEDITL 800 ESERKRIFKD 810 FMHVLEHECQ 820 HHHSKNKKHS 830 KKSKKHHRKR 840 SRSRSGSDSD 850 DDDSHSKKKR 860 QRSESRSASE 870 HSSSAESERS 880 YKKSKKHKKK 890 SKKRRHKSDS 900 PESDAEREKD 910 KKEKDRESEK 920 DRTRQRSESK 930 HKSPKKKTGK 940 DSGNWDTSGS 950 ELSEGELEKR 960 RRTLLEQLDD DQ

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0016363	nuclear matrix
Cellular Component	GO:0016607	nuclear speck
Biological Process	GO:0045292	mRNA cis splicing, via spliceosome

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.