Overview
| Uniprot ID | A0A286ZIZ9 |
|---|
| Protein Name | Oligoribonuclease, mitochondrial |
|---|
| Gene Name | REXO2 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 108 |
HGKSGLTKAVKESTM |
| 173 |
IIDVSTVKELCRRWY |
| 225 |
KTDEKKRKIIENGEN |
Function
3'-to-5'exoribonuclease that preferentially degrades DNA and RNA oligonucleotides composed of only two nucleotides. Binds and degrades longer oligonucleotides with a lower affinity. Plays dual roles in mitochondria, scavenging nanoRNAs (small RNA oligonucleotides of <5 nucleotides) that are produced by the degradosome and clearing short RNAs that are generated by RNA processing. Essential for correct initiation of mitochondrial transcription, degrading mitochondrial RNA dinucleotides to prevent RNA-primed transcription at non-canonical sites in the mitochondrial genome. Essential for embryonic development
Protein Sequence
10
MLGGSLGCRL
20
LRGVGGTRRQ
30
FGARGVREGG
40
AAMAAGESMA
50
QRMVWVDLEM
60
TGLDIEKDQI
70
IEMACLITDS
80
DLNILAEGPN
90
LIIKQPDELL
100
DSMSDWCKEH
110
HGKSGLTKAV
120
KESTMTLQQA
130
EYEFLSFVRQ
140
QTPPGLCPLA
150
GNSVHADKKF
160
LDKYMPQFMK
170
HLHYRIIDVS
180
TVKELCRRWY
190
PEEYEFAPKK
200
AASHRALDDI
210
SESIKELQFY
220
RNNIFKKKTD
230
EKKRKIIENG
ENEKTVS
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005758 |
mitochondrial intermembrane space |
| Cellular Component |
GO:0005759 |
mitochondrial matrix |
| Cellular Component |
GO:0005739 |
mitochondrion |
| Cellular Component |
GO:0005634 |
nucleus |
| Molecular Function |
GO:0008296 |
3'-5'-DNA exonuclease activity |
| Molecular Function |
GO:0000175 |
3'-5'-RNA exonuclease activity |
| Molecular Function |
GO:0000287 |
magnesium ion binding |
| Molecular Function |
GO:0003676 |
nucleic acid binding |
| Biological Process |
GO:2000827 |
mitochondrial RNA surveillance |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.