Overview
| Uniprot ID | A0A286ZJ05 |
|---|
| Protein Name | ADP-ribosylation factor GTPase-activating protein 1 |
|---|
| Gene Name | ARFGAP1 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 226 |
SRFASAAKEGATKFG |
Function
GTPase-activating protein (GAP) for the ADP ribosylation factor 1 (ARF1). Involved in membrane trafficking and /or vesicle transport. Promotes hydrolysis of the ARF1-bound GTP and thus, is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles, a prerequisite for vesicle's fusion with target compartment. Probably regulates ARF1-mediated transport via its interaction with the KDELR proteins and TMED2. Overexpression induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, as when ARF1 is deactivated. Its activity is stimulated by phosphoinosides and inhibited by phosphatidylcholine
Protein Sequence
10
MASPRTRKVL
20
KEIRVQDGNN
30
VCFECGAFNP
40
QWVSVSYGIW
50
ICLECSGRHR
60
GLGVHLSFVR
70
SVTMDKWKDA
80
ELEKMKAGGN
90
AKFQEFLESQ
100
EDYDPGWSLQ
110
EKYNSKAAAL
120
FRDKVATVAE
130
GGEWSLESSP
140
ARNWTPPRPK
150
MLPTCAHGAT
160
GRPQNSTASS
170
DKAFEDWLND
180
DLGSYQGAPE
190
NRYVGFGNTV
200
PPQKKEDDFL
210
NSAMSSLYSG
220
WSSFTTGASR
230
FASAAKEGAT
240
KFGSQASQKF
250
WGSKQQPEPA
260
SELGHSLNES
270
VLKPAQEKVK
280
EGKIFDDVTS
290
GVSQLASKGA
300
GSRGWRDVTT
310
FFSGRTEDSS
320
DRPPEGQSHQ
330
NSGGDHSQSS
340
PFDPGFWEAF
350
GSADPAKAHR
360
SPSSDSWTCA
370
DASADRRSSD
380
SWDVWGSGSA
390
SNNKNSDSGD
400
GGEAWGGGGE
410
GRAKVTKKAA
420
PPPAVDEGWD
NQDW
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0000139 |
Golgi membrane |
| Cellular Component |
GO:0045202 |
synapse |
| Molecular Function |
GO:0005096 |
GTPase activator activity |
| Molecular Function |
GO:0008270 |
zinc ion binding |
| Biological Process |
GO:0015031 |
protein transport |
| Biological Process |
GO:0032012 |
regulation of ARF protein signal transduction |
| Biological Process |
GO:0030100 |
regulation of endocytosis |
| Biological Process |
GO:0016192 |
vesicle-mediated transport |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.