Overview
| Uniprot ID | A0A286ZJ28 |
|---|
| Protein Name | - |
|---|
| Gene Name | COPS7B |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 64 |
TAQQNKLKHLTIVSL |
Function
Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively
Protein Sequence
10
MTAHRETTCI
20
YMELRNLLQI
30
MLAEGANAAY
40
LQLLNLFAYG
50
TYPDYIANKE
60
SLPELSTAQQ
70
NKLKHLTIVS
80
LASRMKCIPY
90
SVLLRDLEMR
100
NLRELEDLII
110
EAVYTDIIQG
120
KLDQRNQLLE
130
VDFCIGRDIR
140
KKDINNIVKT
150
LHEWCDGCEA
160
VLLGIEQQVL
170
RANQYKENHS
180
RTQQQVEAEV
190
TNIKKTLKAT
200
ASSSAQEMEQ
210
QLAERECPPH
220
AEQRQPTKKM
230
SKVKGLVSSR
H
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0008180 |
COP9 signalosome |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Biological Process |
GO:0010387 |
COP9 signalosome assembly |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.