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Overview

Uniprot IDA0A286ZJM4
Protein NameDNA replication licensing factor MCM7
Gene NameMCM7
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
10 LKDYALEKEKVKKFL
145 FQGPSSSKPRVIREV
15 LEKEKVKKFLQEFYQ
159 VRADSVGKLVTVRGI
174 VTRVSEVKPRMVVAT
351 IYGHEDVKKALLLLL
596 RREAWASKDATYTSA
648 KDSLLGDKGQTARTQ

Function

Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity

Protein Sequence

10 MALKDYALEK 20 EKVKKFLQEF 30 YQDDELGKKQ 40 FKYGNQLVRL 50 AHREQVAMYI 60 DLDDVTEDDP 70 ELVDSICENT 80 KRYARLFADA 90 VQELLPQYKE 100 REVVNKDVLD 110 VYIEHRLMME 120 QRSRDPGAAR 130 SPQNQYPPEL 140 MRRFELYFQG 150 PSSSKPRVIR 160 EVRADSVGKL 170 VTVRGIVTRV 180 SEVKPRMVVA 190 TYTCDQCGAE 200 TYQPIQSPTF 210 MPLIMCPSQE 220 CQTNRSGGRL 230 YLQTRGSKFI 240 KFQEMKMQEH 250 SDQVPVGNIP 260 RSITVLVEGE 270 NTRIAQPGDH 280 VSVTGIFLPI 290 LRTGFRQVVQ 300 GLLSETYLEA 310 HRIVKMSKSE 320 DDESGAGELS 330 REELRQIAEE 340 DFYEKLAASI 350 APEIYGHEDV 360 KKALLLLLVG 370 GVDQSPRGMK 380 IRGNINICLM 390 GDPGVAKSQL 400 LSYIDRLAPR 410 SQYTTGRGSS 420 GVGLTAAVLR 430 DSVSGELTLE 440 GGALVLADQG 450 VCCIDEFDKM 460 AEADRTAIHE 470 VMEQQTISIA 480 KAGILTTLNA 490 RCSILAAANP 500 AYGRYNPRRS 510 LEQNIQLPAA 520 LLSRFDLLWL 530 IQDRPDRDND 540 LRLAQHITYV 550 HQHSRQPPAQ 560 FEPLDMKLMR 570 RYIAMCREKQ 580 PTVPESLADY 590 ITAAYVEMRR 600 EAWASKDATY 610 TSARTLLAIL 620 RLSTALARLR 630 MVDTVEKEDV 640 NEAIRLMEMS 650 KDSLLGDKGQ 660 TARTQRPADV 670 IFATVRELVS 680 EGRSVRFSEA 690 EQRCISRGFT 700 PAQFQAALDE 710 YEELNVWQVN TARTRITFV

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005694 chromosome
Cellular Component GO:0042555 MCM complex
Cellular Component GO:0005634 nucleus
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0016887 ATP hydrolysis activity
Molecular Function GO:0003678 DNA helicase activity
Molecular Function GO:0003697 single-stranded DNA binding
Biological Process GO:0006270 DNA replication initiation
Biological Process GO:0006271 DNA strand elongation involved in DNA replication
Biological Process GO:0000727 double-strand break repair via break-induced replication

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.