Search Results
Overview
| Uniprot ID | A0A286ZJQ9 |
|---|---|
| Protein Name | Caveolin |
| Gene Name | CAV1 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 5 | ***MSGGKYVDSEGH |
| 57 | DLVNRDPKHLNDDVV |
Function
May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway. Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the internalization of TGFBR1 from membrane rafts leading to its subsequent degradation. Binds 20(S)-hydroxycholesterol (20(S)-OHC)
Protein Sequence
10
MSGGKYVDSE
20
GHLYTVPIRE
30
QGNIYKPNNK
40
AMAEEMNEKQ
50
VYDAHTKEID
60
LVNRDPKHLN
70
DDVVKIDFED
80
VIAEPEGTHS
90
FDGIWKASFT
100
TFTVTKYWFY
110
RLLSALFGIP
120
MALIWGIYFA
130
ILSFLHIWVV
140
PCIKSFLIEI
150
QCISRVYSIY
160
VHTFCDPLFE
170
AIGKIFSNIR
INMQKEI
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0002080 | acrosomal membrane |
| Cellular Component | GO:0005901 | caveola |
| Cellular Component | GO:0002095 | caveolar macromolecular signaling complex |
| Cellular Component | GO:0005938 | cell cortex |
| Cellular Component | GO:0005929 | cilium |
| Cellular Component | GO:0031410 | cytoplasmic vesicle |
| Cellular Component | GO:0005783 | endoplasmic reticulum |
| Cellular Component | GO:0005768 | endosome |
| Cellular Component | GO:0005925 | focal adhesion |
| Cellular Component | GO:0005794 | Golgi apparatus |
| Cellular Component | GO:0000139 | Golgi membrane |
| Cellular Component | GO:0048471 | perinuclear region of cytoplasm |
| Cellular Component | GO:0042383 | sarcolemma |
| Molecular Function | GO:0051117 | ATPase binding |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0070320 | inward rectifier potassium channel inhibitor activity |
| Molecular Function | GO:0060090 | molecular adaptor activity |
| Molecular Function | GO:0050998 | nitric-oxide synthase binding |
| Molecular Function | GO:0008142 | oxysterol binding |
| Molecular Function | GO:0016504 | peptidase activator activity |
| Molecular Function | GO:0046982 | protein heterodimerization activity |
| Molecular Function | GO:0019901 | protein kinase binding |
| Molecular Function | GO:0030292 | protein tyrosine kinase inhibitor activity |
| Molecular Function | GO:0044877 | protein-containing complex binding |
| Molecular Function | GO:0030674 | protein-macromolecule adaptor activity |
| Molecular Function | GO:0005102 | signaling receptor binding |
| Molecular Function | GO:0031267 | small GTPase binding |
| Molecular Function | GO:0044325 | transmembrane transporter binding |
| Biological Process | GO:0038166 | angiotensin-activated signaling pathway |
| Biological Process | GO:0097190 | apoptotic signaling pathway |
| Biological Process | GO:0060070 | canonical Wnt signaling pathway |
| Biological Process | GO:0070836 | caveola assembly |
| Biological Process | GO:0072584 | caveolin-mediated endocytosis |
| Biological Process | GO:0030154 | cell differentiation |
| Biological Process | GO:0071455 | cellular response to hyperoxia |
| Biological Process | GO:0071218 | cellular response to misfolded protein |
| Biological Process | GO:0038016 | insulin receptor internalization |
| Biological Process | GO:2000811 | negative regulation of anoikis |
| Biological Process | GO:0090090 | negative regulation of canonical Wnt signaling pathway |
| Biological Process | GO:0001937 | negative regulation of endothelial cell proliferation |
| Biological Process | GO:0060546 | negative regulation of necroptotic process |
| Biological Process | GO:0048550 | negative regulation of pinocytosis |
| Biological Process | GO:1901380 | negative regulation of potassium ion transmembrane transport |
| Biological Process | GO:0031397 | negative regulation of protein ubiquitination |
| Biological Process | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| Biological Process | GO:0010524 | positive regulation of calcium ion transport into cytosol |
| Biological Process | GO:0043123 | positive regulation of canonical NF-kappaB signal transduction |
| Biological Process | GO:0030335 | positive regulation of cell migration |
| Biological Process | GO:0010875 | positive regulation of cholesterol efflux |
| Biological Process | GO:0120162 | positive regulation of cold-induced thermogenesis |
| Biological Process | GO:1904294 | positive regulation of ERAD pathway |
| Biological Process | GO:2001238 | positive regulation of extrinsic apoptotic signaling pathway |
| Biological Process | GO:1903598 | positive regulation of gap junction assembly |
| Biological Process | GO:0010628 | positive regulation of gene expression |
| Biological Process | GO:2001244 | positive regulation of intrinsic apoptotic signaling pathway |
| Biological Process | GO:0031398 | positive regulation of protein ubiquitination |
| Biological Process | GO:0010608 | post-transcriptional regulation of gene expression |
| Biological Process | GO:0019065 | receptor-mediated endocytosis of virus by host cell |
| Biological Process | GO:0030193 | regulation of blood coagulation |
| Biological Process | GO:0098909 | regulation of cardiac muscle cell action potential involved in regulation of contraction |
| Biological Process | GO:1901844 | regulation of cell communication by electrical coupling involved in cardiac conduction |
| Biological Process | GO:0051480 | regulation of cytosolic calcium ion concentration |
| Biological Process | GO:2000535 | regulation of entry of bacterium into host cell |
| Biological Process | GO:0086091 | regulation of heart rate by cardiac conduction |
| Biological Process | GO:0098903 | regulation of membrane repolarization during action potential |
| Biological Process | GO:1900027 | regulation of ruffle assembly |
| Biological Process | GO:0098911 | regulation of ventricular cardiac muscle cell action potential |
| Biological Process | GO:0009617 | response to bacterium |
| Biological Process | GO:0051592 | response to calcium ion |
| Biological Process | GO:0031295 | T cell costimulation |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.