Search Results
Overview
| Uniprot ID | A0A286ZJW9 |
|---|---|
| Protein Name | Derlin |
| Gene Name | DERL2 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 200 | PGGIRILKTPSILKA |
Function
Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome
Protein Sequence
10
MAYQSLRLEY
20
LQIPPVSRAY
30
TTACVLTTAA
40
VQLELITPFQ
50
LYFNPELIFK
60
HFQIWRLITN
70
FLFFGPVGFN
80
FLFNMIFLYR
90
YCRMLEEGSF
100
RGRTADFVFM
110
FLFGGFLMTL
120
FGLFVSLVFL
130
GQAFTIMLVY
140
VWSRRNPYVR
150
MNFFGLLNFQ
160
APFLPWVLMG
170
FSLLLGNSII
180
VDLLGIAVGH
190
IYFFLEDVFP
200
NQPGGIRILK
210
TPSILKAIFD
220
TPDEDPNYNP
230
LPEERPGGFA
WGEGQRLGG
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005769 | early endosome |
| Cellular Component | GO:0005789 | endoplasmic reticulum membrane |
| Cellular Component | GO:0005770 | late endosome |
| Molecular Function | GO:0005047 | signal recognition particle binding |
| Biological Process | GO:0030968 | endoplasmic reticulum unfolded protein response |
| Biological Process | GO:0036503 | ERAD pathway |
| Biological Process | GO:1904153 | negative regulation of retrograde protein transport, ER to cytosol |
| Biological Process | GO:0030307 | positive regulation of cell growth |
| Biological Process | GO:0008284 | positive regulation of cell population proliferation |
| Biological Process | GO:0030970 | retrograde protein transport, ER to cytosol |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.