Search Results
Overview
| Uniprot ID | A0A286ZK63 |
|---|---|
| Protein Name | Eukaryotic translation initiation factor 5A |
| Gene Name | EIF5A |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 109 | NMDVPNIKRNDFQLI |
| 145 | LPEGDLGKEIEQKYD |
| 51 | MQCSALRKNGFVVLK |
| 58 | KNGFVVLKGRPCKIV |
| 63 | VLKGRPCKIVEMSTS |
| 91 | GIDIFTGKKYEDICP |
| 92 | IDIFTGKKYEDICPS |
Function
Translation factor that promotes translation elongation and termination, particularly upon ribosome stalling at specific amino acid sequence contexts. Binds between the exit (E) and peptidyl (P) site of the ribosome and promotes rescue of stalled ribosome: specifically required for efficient translation of polyproline-containing peptides as well as other motifs that stall the ribosome. Acts as ribosome quality control (RQC) cofactor by joining the RQC complex to facilitate peptidyl transfer during CAT tailing step
Protein Sequence
10
MGSETRGPPH
20
STSFLKRLES
30
KPLKMADDLD
40
FETGDAGASA
50
TFPMQCSALR
60
KNGFVVLKGR
70
PCKIVEMSTS
80
KTGKHGHAKV
90
HLVGIDIFTG
100
KKYEDICPST
110
HNMDVPNIKR
120
NDFQLIGIQD
130
GYLSLLQDSG
140
EVREDLRLPE
150
GDLGKEIEQK
160
YDCGEEILIT
170
VLSAMTEEAA
VAIKAMAK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005789 | endoplasmic reticulum membrane |
| Molecular Function | GO:0043022 | ribosome binding |
| Molecular Function | GO:0003723 | RNA binding |
| Molecular Function | GO:0003746 | translation elongation factor activity |
| Biological Process | GO:0045901 | positive regulation of translational elongation |
| Biological Process | GO:0045905 | positive regulation of translational termination |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.