Search Results

Overview

Uniprot IDA0A286ZKD4
Protein NameElectrogenic aspartate/glutamate antiporter SLC25A13, mitochondrial
Gene NameSLC25A13
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
23 ELRTIFLKYASIEKN
235 NNMELIRKIYSTLAG
379 KNSFDCFKKVLRYEG
408 VAPEKAIKLTVNDFV
487 FGIYKGAKACFLRDI
5 ***MAVAKVALTKRA

Function

Mitochondrial electrogenic aspartate/glutamate antiporter that favors efflux of aspartate and entry of glutamate and proton within the mitochondria as part of the malate-aspartate shuttle. Substrate exchange across the membrane occurs consecutively with one substrate being transported first, then dissociating from the substrate binding site before the second substrate binds for transport in the opposite direction. Also mediates the uptake of L-cysteinesulfinate (3-sulfino-L-alanine) by mitochondria in exchange for L-glutamate and proton. Can also exchange L-cysteinesulfinate with aspartate in their anionic form without any proton translocation. Lacks transport activity towards gamma-aminobutyric acid (GABA)

Protein Sequence

10 MAVAKVALTK 20 RADPAELRTI 30 FLKYASIEKN 40 GEFFMSPNDF 50 VTRYLNIFGE 60 SQPNPKTVEL 70 LSGVVDQTKD 80 GLISFQEFVA 90 FESVLCAPDA 100 LFMVVFQLFD 110 KAGKGEVTFE 120 DVKQVFEQTT 130 IHQRIPFNWD 140 SEFVQLHFGK 150 ERKRHLTYAE 160 FTQFLLEIQL 170 EHAKQAFVQR 180 DSAKTGKVTA 190 IDFRDIMVTI 200 RPHVLTPFVE 210 ECLVAAAGGT 220 TSHQVSFSYF 230 NGFNSLLNNM 240 ELIRKIYSTL 250 AGNRKDVEVT 260 KEEFVLAAQK 270 FGQVTPMEVD 280 ILFQLADLYE 290 PRGRMTLADI 300 ERIAPLEEGT 310 LPFNLAEAQR 320 QKASVDSSRP 330 VLLQIAESAY 340 RFGLGSVAGA 350 VGATAVYPID 360 LVKTRMQNQR 370 STGSFVGELM 380 YKNSFDCFKK 390 VLRYEGFFGL 400 YRGLLPQLLG 410 VAPEKAIKLT 420 VNDFVRDKFM 430 RKDGSVPLAA 440 EILAGGCAGG 450 SQVIFTNPLE 460 IVKIRLQVAG 470 EITTGPRVSA 480 LSVLRDLGFF 490 GIYKGAKACF 500 LRDIPFSAIY 510 FPCYAHVKAS 520 LASEDGQISP 530 GSLLLAGAIA 540 GMPAASLVTP 550 ADVIKTRLQV 560 AARAGQTTYS 570 GVIDCFWKIL 580 REEGPKALWK 590 GAGARVFRSS 600 PQFGVTLLTY 610 ELLQRWFYID 620 FGGVKPMGSE 630 PVPKSRITLP 640 APNPDHVGGY 650 KLAVATFAGI 660 ENKFGLYLPL 670 FKPSASTSQA 680 LREAHRRTSP GLLL

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005743 mitochondrial inner membrane
Molecular Function GO:0000514 3-sulfino-L-alanine: proton, glutamate antiporter activity
Molecular Function GO:0000515 aspartate:glutamate, proton antiporter activity
Molecular Function GO:0005509 calcium ion binding
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0015183 L-aspartate transmembrane transporter activity
Molecular Function GO:0005313 L-glutamate transmembrane transporter activity
Biological Process GO:0015810 aspartate transmembrane transport
Biological Process GO:0006754 ATP biosynthetic process
Biological Process GO:0045333 cellular respiration
Biological Process GO:0006094 gluconeogenesis
Biological Process GO:0015813 L-glutamate transmembrane transport
Biological Process GO:0043490 malate-aspartate shuttle
Biological Process GO:0051592 response to calcium ion

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.