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Overview

Uniprot ID	A0A286ZKJ2
Protein Name	ATP-dependent 6-phosphofructokinase
Gene Name	PFKM
Organism	Sus scrofa

Kla Sites from experimental identification

Position	Flanking peptide
678	FDRNFATKMGAKAMN

Function

Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis

Protein Sequence

10 MTHEEHHAAK 20 SLGVGKAIAV 30 LTSGGDAQGM 40 NAAVRAVVRV 50 GIYTGARVFF 60 VHEGYQGLVD 70 GGDNIREATW 80 ESVSMMLQLG 90 GTVIGSARCK 100 DFREREGRLR 110 AAHNLVKRGI 120 TNLCVIGGDG 130 SLTGADTFRS 140 EWGDLLNDLQ 150 KAGKITAEEA 160 NKSSYLNIVG 170 LVGSIDNDFC 180 GTDMTIGTDS 190 ALHRIIEIVD 200 AITTTAQSHQ 210 RTFVLEVMGR 220 HCGYLALVTS 230 LSCGADWVFI 240 PECPPDDAWE 250 EHLCRRLSET 260 RTRGSRLNII 270 IVAEGAIDKN 280 GQPITSENIK 290 DLVVKRLGYD 300 TRVTVLGHVQ 310 RGGTPSAFDR 320 ILGSRMGVEA 330 VMALLEGTPD 340 TPACVVSLSG 350 NQAVRLPLME 360 CVQVTKDVTK 370 AMNEKRFDEA 380 MKLRGRSFMN 390 NWEVYKLLAH 400 VRPPVTKSGS 410 YTVAVMNVGA 420 PAAGMNAAVR 430 STVRIGLIQG 440 NRVLVVHDGF 450 EGLAKGQIEE 460 AGWSYVGGWT 470 GQGGSKLGTK 480 RTLPKKSFEQ 490 ISANITKFNI 500 QGLVIIGGFE 510 AYTGGLELME 520 GRKQYDELCI 530 PFVVIPATVS 540 NNVPGSDFSV 550 GADTALNTIC 560 MTCDRIKQSA 570 AGTKRRVFII 580 ETMGGYCGYL 590 ATMAGLAAGA 600 DAAYIFEEPF 610 TIRDLQVNVE 620 HLVQKMKTTV 630 KRGLVLRNEK 640 CNENYTTDFI 650 FNLYSEEGKG 660 IFDSRKNVLG 670 HMQQGGSPTP 680 FDRNFATKMG 690 AKAMNWMSGK 700 IKESYRNGRI 710 FANTPDSGCV 720 LGMRKRALVF 730 QPVTELKEQT 740 DFEHRIPKEQ 750 WWLKLRPILK 760 ILAKYEIDLD 770 TSEHAHLEHI 780 TRKRSGEATI

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005737	cytoplasm
Molecular Function	GO:0003872	6-phosphofructokinase activity
Molecular Function	GO:0005524	ATP binding
Molecular Function	GO:0046872	metal ion binding
Biological Process	GO:0006002	fructose 6-phosphate metabolic process

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.