Overview
| Uniprot ID | A0A286ZKQ1 |
|---|
| Protein Name | Beta-hexosaminidase |
|---|
| Gene Name | HEXB |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 377 |
NMISAMKKRPIVWQE |
Function
Hydrolyzes the non-reducing end N-acetyl-D-hexosamine and/or sulfated N-acetyl-D-hexosamine of glycoconjugates, such as the oligosaccharide moieties from proteins and neutral glycolipids, or from certain mucopolysaccharides. The isozyme B does not hydrolyze each of these substrates, however hydrolyzes efficiently neutral oligosaccharide. Only the isozyme A is responsible for the degradation of GM2 gangliosides in the presence of GM2A. During fertilization is responsible, at least in part, for the zona block to polyspermy. Present in the cortical granules of non-activated oocytes, is exocytosed during the cortical reaction in response to oocyte activation and inactivates the sperm galactosyltransferase-binding site, accounting for the block in sperm binding to the zona pellucida
Protein Sequence
10
MEVPRWLPGL
20
LALLAALVVP
30
KGWARDTSGA
40
ESLGLWPLPF
50
AVDISPRSLH
60
LSPNNFFFGH
70
SPTSKAGSSC
80
EILQEAFRRY
90
YDFIFGFYKW
100
HQGSYQLCFG
110
TELQQLQVHV
120
ESECDTFPSI
130
SSNESYVLHV
140
KGPEALLRAN
150
TVWGALRGLE
160
TFSQLIYQDS
170
YGTFTVNESE
180
IIDFPRFPHR
190
GILIDTGRHF
200
LSVKTIFKTL
210
DAMAFNKFNV
220
LHWHIVDDQS
230
FPYQSINFPL
240
LSSKGSYSLS
250
HVYTPNDVRM
260
VIEYARIRGI
270
RVMPEFDTPG
280
HSRSWGKGQK
290
DLLTPCYRKQ
300
VLSGTFGPIN
310
PILNTTYNFL
320
SKFFKEISTV
330
FPDEFIHIGG
340
DEVDFDCWAS
350
NSEILQFMQE
360
KGFSKNFTKL
370
QSFYVFKISN
380
MISAMKKRPI
390
VWQEAFDGRD
400
KFMPGTVVQV
410
WKIEDYKWEQ
420
SLITKAGFPV
430
ILSAPWYLDL
440
ISYGQDWKNY
450
YEVEPQDFPG
460
SDKERKRVLG
470
GEACLWGEYV
480
DATNLTPRLW
490
PRASAVGERL
500
WSHKDVRDIH
510
DAYSRLTIHR
520
CRMVRRGIAA
530
EPLFTGYCNH
EHRM
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0060473 |
cortical granule |
| Cellular Component |
GO:0005764 |
lysosome |
| Molecular Function |
GO:0004563 |
beta-N-acetylhexosaminidase activity |
| Biological Process |
GO:1901135 |
carbohydrate derivative metabolic process |
| Biological Process |
GO:0005975 |
carbohydrate metabolic process |
| Biological Process |
GO:0006629 |
lipid metabolic process |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.