Overview
| Uniprot ID | A0A286ZKQ3 |
|---|
| Protein Name | Polypyrimidine tract-binding protein 1 |
|---|
| Gene Name | PTBP1 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 104 |
YIQFSNHKELKTDSS |
| 107 |
FSNHKELKTDSSPNQ |
| 229 |
TLRIDFSKLTSLNVK |
| 236 |
KLTSLNVKYNNDKSR |
| 338 |
YGDVQRVKILFNKKE |
| 380 |
PVRITLSKHQNVQLP |
| 398 |
QEDQGLTKDYGNSPL |
| 455 |
GGIVKGFKFFQKDRK |
Function
Plays a role in pre-mRNA splicing and in the regulation of alternative splicing events. Activates exon skipping of its own pre-mRNA during muscle cell differentiation. Binds to the polypyrimidine tract of introns. May promote RNA looping when bound to two separate polypyrimidine tracts in the same pre-mRNA. May promote the binding of U2 snRNP to pre-mRNA. Cooperates with RAVER1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA. Represses the splicing of MAPT/Tau exon 10. Binds to polypyrimidine-rich controlling element (PCE) of CFTR and promotes exon skipping of CFTR exon 9, thereby antagonizing TIA1 and its role in exon inclusion of CFTR exon 9. Plays a role in the splicing of pyruvate kinase PKM by binding repressively to a polypyrimidine tract flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform
Protein Sequence
10
MSSNSASTAN
20
GNDSKKFKGD
30
NRSAGVPSRV
40
IHIRKLPSDV
50
TEGEVISLGL
60
PFGKVTNLLM
70
LKGKNQAFIE
80
MNTEEAANTM
90
VNYYTSVTPV
100
LRGQPIYIQF
110
SNHKELKTDS
120
SPNQARAQAA
130
LQAVNSVQSG
140
NLALAASAAA
150
VDAGMAMAGQ
160
SPVLRIIVEN
170
LFYPVTLDVL
180
HQIFSKFGTV
190
LKIITFTKNN
200
QFQALLQYAD
210
PVSAQHAKLS
220
LDGQNIYNAC
230
CTLRIDFSKL
240
TSLNVKYNND
250
KSRDYTRPDL
260
PSGDNQPSLD
270
QTMAAAFGLS
280
VPNVHGALAP
290
LAIPSAAAAA
300
AAAGRIAIPG
310
LAGAGNSVLL
320
VSNLNPERVT
330
PQSLFILFGV
340
YGDVQRVKIL
350
FNKKENALVQ
360
MADGSQAQLA
370
MSHLNGHKLH
380
GKPVRITLSK
390
HQNVQLPREG
400
QEDQGLTKDY
410
GNSPLHRFKK
420
PGSKNFQNIF
430
PPSATLHLSN
440
IPPSISEEDL
450
KILFSSNGGI
460
VKGFKFFQKD
470
RKMALIQMGS
480
VEEAIQALID
490
LHNHDLGENH
500
HLRVSFSKST
I
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005634 |
nucleus |
| Molecular Function |
GO:0003723 |
RNA binding |
| Biological Process |
GO:0006397 |
mRNA processing |
| Biological Process |
GO:0010629 |
negative regulation of gene expression |
| Biological Process |
GO:1903312 |
negative regulation of mRNA metabolic process |
| Biological Process |
GO:0008380 |
RNA splicing |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.