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Overview

Uniprot IDA0A286ZKS6
Protein NameHepatocyte growth factor-regulated tyrosine kinase substrate
Gene NameHGS
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
218 SRCSTIPKFGIEKEV
223 IPKFGIEKEVRVCEP
237 PCYEQLNKKAEGKAA
50 KYAVSSIKKKVNDKN

Function

Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. May contribute to the efficient recruitment of SMADs to the activin receptor complex. Involved in receptor recycling via its association with the CART complex, a multiprotein complex required for efficient transferrin receptor recycling but not for EGFR degradation

Protein Sequence

10 MGRGSGTFER 20 LLDKATSQLL 30 LETDWESILQ 40 ICDLIRQGDT 50 QAKYAVSSIK 60 KKVNDKNPHV 70 ALYALEDPLE 80 QWPRPSPPRG 90 LQVMESVVKN 100 CGQTVHDEVA 110 NKQTMEELKE 120 LLKRQVEVSV 130 RNKILHLIQA 140 WAHAFRNEPK 150 YKVVQDTYQI 160 MKVEGHVFPE 170 FKESDAMFAA 180 ERAPDWVDAE 190 ECHRCRVQFG 200 VMTRKHHCRA 210 CGQIFCGKCS 220 SRCSTIPKFG 230 IEKEVRVCEP 240 CYEQLNKKAE 250 GKAASTELPP 260 EYLTSPLSQQ 270 SQLPPKRDET 280 ALQEEEELQL 290 ALALSQSEAE 300 EKERTRQKSA 310 YAAYPKAEPA 320 SVASSAPPAS 330 SLYSSPVNSS 340 APLAEDIDPE 350 LARYLNRNYW 360 EKKQEEARKS 370 PTPSAPVPLA 380 EPAAQPGEGH 390 AVPASVETPL 400 PEGDPQPVTP 410 AGGPFGEYQN 420 GESEESHAQF 430 LKALQNAVST 440 FVNRVRSNHV 450 RGRSITNDSA 460 VLSLFQSING 470 MHPQLLELLN 480 QLDERRLYYE 490 GLQDKLAQIR 500 DARGALSALR 510 EEHREKLRRA 520 AEEAERQRQI 530 QLAQKLEIMR 540 QKKQEYLEVQ 550 RQLAIQRLQE 560 QEKERQLRLE 570 QQKQTIQMRA 580 QMPAFSLPYA 590 QLQAMPTAGG 600 VLYQPSGPAS 610 FAGTFSPAGS 620 VEGSPMHTVY 630 MSQPAPAAGG 640 PYPSLPGAAA 650 DPSMVGAYMY 660 PAGATGAQTA 670 PPGPAGPTAS 680 PAYSSYQPSP 690 AQAYQNVASQ 700 PPQSLPAVSQ 710 PPQAGALGYV 720 GGQAVSVGYQ 730 PYGMQGLLTA 740 LPGQDAPLPP 750 PQQPYLTGQQ 760 PVYQQMAPSG 770 GPPQQQPPVA 780 QQPPAQGPPA 790 QGSEAQLISF D

Gene Ontology

Classification GO ID Description
Cellular Component GO:0031901 early endosome membrane
Cellular Component GO:0032585 multivesicular body membrane
Molecular Function GO:0035091 phosphatidylinositol binding
Molecular Function GO:0019904 protein domain specific binding
Molecular Function GO:0043130 ubiquitin binding
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0015031 protein transport

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.