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Overview

Uniprot IDA0A286ZKS9
Protein NameSWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1
Gene NameSMARCAD1
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
322 SRSQNYPKNAAKTKL

Function

Protein that possesses intrinsic ATP-dependent nucleosome-remodeling activity and is both required for DNA repair and heterochromatin organization. Combines the ATP-dependent ability to exchange histones, with the chaperone-like ATP-independent activity to deposit histones and assemble nucleosomes. Promotes DNA end resection of double-strand breaks (DSBs) following DNA damage: probably acts by weakening histone DNA interactions in nucleosomes flanking DSBs. Required for the restoration of heterochromatin organization after replication. Acts at replication sites to facilitate the maintenance of heterochromatin by directing H3 and H4 histones deacetylation, H3 'Lys-9' trimethylation (H3K9me3) and restoration of silencing

Protein Sequence

10 MNLFNLDRFR 20 FEKRNKIEEA 30 PEATPQPSRP 40 GPSSPISLSA 50 EEENAEGEVS 60 RAGTPDSDVT 70 EKTEDSSVPE 80 MPENERKAGI 90 SYFKNQRGIQ 100 YIDLSSDSED 110 IISPNCSSTV 120 QEKKFNKDTV 130 IIVSEPSEDE 140 ESQGLPTVAG 150 RNNNDLSELE 160 DLSELEDLKD 170 AKLQTLKELF 180 PQRSDSDLLK 190 LIESTSTMDG 200 AIAAALLMFG 210 DAGGGPRKRK 220 LSSSSEPYEE 230 DEFNDDQSIK 240 KKRLDHGEES 250 NESAESSSNW 260 EKQESIVLKL 270 QKEFPNFDKE 280 ELREVLKEHE 290 WMYTEALESL 300 KVFAEDQDMQ 310 YASPSEFPNG 320 KEVSSRSQNY 330 PKNAAKTKLK 340 QKCSMKPQNG 350 FNKKRKKNVF 360 NPKRVIEDSE 370 YDSGSDVGSS 380 LDEDYSSGEE 390 VMEDGYKGKI 400 LHFLQDASIG 410 ELTLIPQCSQ 420 KKAQKITELR 430 PFNSWEALFT 440 KMSKTNGLSE 450 DLIWHCKTLI 460 QERDVVIRLM 470 NKCEDISNKL 480 TKQVTMLTGN 490 GGGWNIEQPS 500 ILNQSLSLKP 510 YQKVGLNWLA 520 LVHKHGLNGI 530 LADEMGLGKT 540 IQAIAFLAYL 550 YQEGNKGPHL 560 IVVPASTIDN 570 WLREVNLWCP 580 TLKVLCYYGS 590 QEERKQIRYN 600 IHSKYEEYNV 610 IVTTYNCAIS 620 SSDDRSLFRR 630 LKLNYAIFDE 640 GHMLKNMGSI 650 RYQHLMTINA 660 NNRLLLTGTP 670 VQNNLLELMS 680 LLNFVMPHMF 690 SSSTSEIRRM 700 FSSKTKSADE 710 QSIYEKERIA 720 HAKQIIKPFI 730 LRRVKEEVLK 740 QLPPKKDQIE 750 LCAMSEKQEQ 760 LYLGLFNRLK 770 KSINNMVTEK 780 NTEMCNVMMQ 790 LRKMANHPLL 800 HRQYYTAEKL 810 KEMSQLMLKE 820 PTHCEANPDL 830 IFEDMEVMTD 840 FELHVLCKQY 850 RHINNFQLDM 860 DLILDSGKFR 870 VLGCILSELK 880 QKGDRVVLFS 890 QFTMMLDILE 900 VLLKHHQHRY 910 LRLDGKTQIS 920 ERIHLIDEFN 930 TDMDIFVFLL 940 STKAGGLGIN 950 LTSANVVILH 960 DIDCNPYNDK 970 QAEDRCHRVG 980 QTKEVLVIKL 990 ISQGTIEESM 1000 LKINQQKLKL 1010 EQDMTTIDEG 1020 DEGSMPADIA TLLKTSMGL

Gene Ontology

Classification GO ID Description
Cellular Component GO:0000785 chromatin
Cellular Component GO:0000792 heterochromatin
Cellular Component GO:0043596 nuclear replication fork
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0035861 site of double-strand break
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0140674 ATP-dependent histone chaperone activity
Molecular Function GO:0003682 chromatin binding
Molecular Function GO:0003677 DNA binding
Molecular Function GO:0003678 DNA helicase activity
Molecular Function GO:0016787 hydrolase activity
Molecular Function GO:0140750 nucleosome array spacer activity
Molecular Function GO:0043130 ubiquitin binding
Biological Process GO:0051304 chromosome separation
Biological Process GO:0000729 DNA double-strand break processing
Biological Process GO:0031507 heterochromatin formation
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0000018 regulation of DNA recombination

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.