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Overview

Uniprot ID	A0A286ZKU3
Protein Name	RB1-inducible coiled-coil protein 1
Gene Name	RB1CC1
Organism	Sus scrofa

Kla Sites from experimental identification

Position	Flanking peptide
1015	DHRVCLEKLEKENQQ

Function

Involved in autophagy. Regulates early events but also late events of autophagosome formation through direct interaction with Atg16L1. Required for the formation of the autophagosome-like double-membrane structure that surrounds the Salmonella-containing vacuole (SCV) during S.typhimurium infection and subsequent xenophagy. Involved in repair of DNA damage caused by ionizing radiation, which subsequently improves cell survival by decreasing apoptosis. Inhibits PTK2/FAK1 and PTK2B/PYK2 kinase activity, affecting their downstream signaling pathways. Plays a role as a modulator of TGF-beta-signaling by restricting substrate specificity of RNF111. Functions as a DNA-binding transcription factor. Is a potent regulator of the RB1 pathway through induction of RB1 expression. Plays a crucial role in muscular differentiation. Plays an indispensable role in fetal hematopoiesis and in the regulation of neuronal homeostasis

Protein Sequence

10 MKLYVFLVNT 20 GTTLTFDTEL 30 TVQTVADLKH 40 AIHSKYKIAA 50 QHQVLVVNGG 60 ECMAADRRVC 70 TYSAGTDTNP 80 IFLFNKEMIL 90 SERLPAIPKT 100 TFSTENDMEI 110 KVEESLMMPA 120 VFHTVASRTQ 130 LAVEMYEVAK 140 KLCSFCEGLV 150 HDEHLQHQGW 160 AAIMANLEDC 170 SNSYQKLLFK 180 FESIYSNYLQ 190 SVEDIKLKLT 200 HLGTAVSVMA 210 KIPLLECLTR 220 HSYRECLGRL 230 DSLPEHEGSE 240 EAETKTSADL 250 VLSPEMPATP 260 IKPLSTSCLK 270 AAEHVAPEAT 280 DAESGKEIRE 290 SGQNTAQLDE 300 TSVDAKDGDL 310 PFFNVSLLDW 320 INVQDRPNDV 330 ESLVRKCFDS 340 MSRLDPRIIR 350 PFIAECRQTI 360 ANLDNQNMKA 370 IKGLEDRLYA 380 LDQMIASCGR 390 LVNEQKELAQ 400 GFLANQMRAE 410 NLKDASVLPD 420 LCLSHANQLM 430 IMLQNHRKLL 440 DIKQKCTTAK 450 QELANNLHVR 460 LKWCCFVMLH 470 ADQDGEKLQA 480 LLRLVMELLE 490 RVRIVEALST 500 VPQMYCLAVV 510 EVVRRKMFIQ 520 HYREWAGALV 530 RDGKRLYEAE 540 KSKRESFGKL 550 FRKSFLRNRL 560 FRGLDSWPPS 570 FCTQKPRKFD 580 CELPDISLKD 590 LQFLQSFCPS 600 EVQPFLRVPL 610 LCDFEPLHQH 620 ALALHNLVKA 630 AQSLDEMSQT 640 ITDLLSEQKA 650 SVSQTTPQSA 660 SSPRVESATG 670 MTTTTSPRTP 680 PPLDVQDPLC 690 PAVCPLEELS 700 PDSIDAHTFD 710 FETIPHPNIE 720 QTLHQASLDL 730 DSLAESPESD 740 FMSAVNEFVI 750 EENLSSPNPI 760 SDPQSPEMMV 770 ESLYSSVINA 780 IDSRRMQDTN 790 TCGQEDAGGR 800 ASLSVQLEKC 810 RVTAHDSHLS 820 IQTIKEDLCH 830 FRTFVQKEQG 840 DFSNSLKCTA 850 VEIRNIIEKV 860 KHSLEITLNE 870 NHQRELQSLK 880 SDYEGRLAAL 890 VKESEESENR 900 ITQLKGDLAC 910 LEEVLQNKDN 920 EFALVKHEKE 930 VVVGLQNEKD 940 QKLLAMEGLL 950 RTQHGEIEGL 960 KQSREMALED 970 LERLREEHEA 980 RMQLLRAELQ 990 RSEQSHLKEL 1000 EDTLQARHTQ 1010 ELERSLADHR 1020 VCLEKLEKEN 1030 QQRLEQVQNS 1040 HAAVIQEREQ 1050 QLQELKLKVS 1060 DLSDMRCKLE 1070 VELALKEAET 1080 DEIKLLLEES 1090 RAQQKETLKS 1100 LLEQETEYLR 1110 SEISKLNQKI 1120 QDHNEHYQVG 1130 LAELRTLMTI 1140 EKDECISELI 1150 TRHEGESTML 1160 RAELSKVTSL 1170 HHHALEIEKS 1180 LREELAELQR 1190 KLDSELSALE 1200 KQKDEKIIQQ 1210 EEKYEAIIQK 1220 LEKDKEEFVI 1230 RQEQDRELLI 1240 QKLNCEKAKA 1250 ADIEAALKEF 1260 NLEREAVEKE 1270 LLERVKHLES 1280 QIAESHAIES 1290 AREDSSSLVA 1300 ELQEKLQEEK 1310 AKFLEQLEEQ 1320 EKRKNEEMQN 1330 VRTSLIAEQQ 1340 TNFNTVLTRE 1350 KMRKENIIND 1360 LSDKLKSTMQ 1370 QQERDKDLIE 1380 SLSADRARLL 1390 EEKKRLEEEV 1400 GRLRGAGPVP 1410 SPSAVAPELY 1420 GACAAAEPPG 1430 EAERPLLPEA 1440 PDEGRADPAL 1450 ETSTMSVQEN 1460 VHMLSEEKQR 1470 IMLLERTLQL 1480 KEEENKRLNQ 1490 RLMSQSLSSV 1500 SPRHSEKIAI 1510 RDFQVGDLVL 1520 IILDERHDNY 1530 VLFTVSPTLY 1540 FLHSESLPAL 1550 DLKPGEGASG 1560 ASRRPWVLGK 1570 VMEKEYCQAK 1580 KVRPPGGRGP 1590 GGEQGLRAAA 1600 CKLWTVPFLV FLCTHVRP

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:1990316	Atg1/ULK1 kinase complex
Cellular Component	GO:0000421	autophagosome membrane
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0005764	lysosome
Cellular Component	GO:0005634	nucleus
Cellular Component	GO:0034045	phagophore assembly site membrane
Molecular Function	GO:0019901	protein kinase binding
Biological Process	GO:0000045	autophagosome assembly
Biological Process	GO:0006351	DNA-templated transcription
Biological Process	GO:0008285	negative regulation of cell population proliferation
Biological Process	GO:0010508	positive regulation of autophagy

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.