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Overview

Uniprot ID	A0A286ZKW5
Protein Name	Glycerol-3-phosphate dehydrogenase
Gene Name	GPD2
Organism	Sus scrofa

Kla Sites from experimental identification

Position	Flanking peptide
165	GTSSRSTKLIHGGVR
323	RVSGARCKDVLTGQE

Function

Calcium-responsive mitochondrial glycerol-3-phosphate dehydrogenase which seems to be a key component of the pancreatic beta-cell glucose-sensing device

Protein Sequence

10 MGWALALFRL 20 KNGISKGSER 30 DSSCWRRCSC 40 HYSRPLSVCS 50 LQKEAIPVRK 60 LMGKEDECLL 70 TSFDCVHLQG 80 MRFMFTNGIH 90 TPSPLQVNLA 100 FVEAADCVSE 110 PVNREPPSRE 120 AQILTLKNTT 130 EFDVLVIGGG 140 ATGSGCALDA 150 VTRGLKTALV 160 ERDDFSSGTS 170 SRSTKLIHGG 180 VRYLQKAIMK 190 LDIEQYRMVK 200 EALHERANLL 210 EIAPHLSAPL 220 PIMLPIYKWW 230 QLPYYWVGIK 240 LYDLVAGSNC 250 LKSSYVLSKS 260 RALEHFPMLQ 270 KDKLVGAIVY 280 YDGQHNDARM 290 NLAIALTAAR 300 YGAATANYME 310 VVSLLKKTDP 320 QTGKERVSGA 330 RCKDVLTGQE 340 FDVRAKCVIN 350 ATGPFTDTVR 360 RMDDKDATAI 370 CQPSAGVHIV 380 MPGYYSPESM 390 GLLDPATSDG 400 RVIFFLPWQK 410 MTIAGTTDTP 420 TDVTNHPIPS 430 EEDINFILNE 440 VRNYLSSDVE 450 VRRGDVLAAW 460 SGIRPLVTDP 470 KSADTQSISR 480 NHVVDISESG 490 LITIAGGKWT 500 TYRSMAEDTI 510 NAAVKAHNLN 520 AGPSRTVGLF 530 LQGGKDWSPT 540 LYIRLVQDYG 550 LESEVAQHLA 560 ATYGDKAFEV 570 AKMASVTGKR 580 WPIVGVRLVS 590 EFPYIEAEVK 600 YGIKEYACTA 610 VDMISRRTRL 620 AFLNVQAAEE 630 ALPRIVELMG 640 RELNWNDSKK 650 EEELETARKF 660 LYYEMGYKSR 670 SEQLTDRSEI 680 SLLPSDIDRY 690 KKRFHKFDAD 700 QKGFITIVDV 710 QRVLESINVQ 720 MDENTLHEIL 730 NEVDLNKNGQ 740 VELNEFLQLM 750 SAIQKGRVSG 760 SRLAILMKTA 770 EENLDRRVPI PVDRSCGGL

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005743	mitochondrial inner membrane
Cellular Component	GO:0005739	mitochondrion
Molecular Function	GO:0005509	calcium ion binding
Molecular Function	GO:0004368	glycerol-3-phosphate dehydrogenase (quinone) activity
Biological Process	GO:0006072	glycerol-3-phosphate metabolic process
Biological Process	GO:0006127	glycerol-3-phosphate shuttle

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.