Search Results

Overview

Uniprot ID	A0A286ZL32
Protein Name	Protein 4.1
Gene Name	EPB41L3
Organism	Sus scrofa

Kla Sites from experimental identification

Position	Flanking peptide
392	RAAKRLWKVCVEHHT
412	LPEAPPKKFLTLGSK

Function

Protein 4.1 is a major structural element of the erythrocyte membrane skeleton. It plays a key role in regulating membrane physical properties of mechanical stability and deformability by stabilizing spectrin-actin interaction. Recruits DLG1 to membranes. Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase

Protein Sequence

10 MGPLLSLFAE 20 QSTMTTESGS 30 DSESKPEQEA 40 EPQEAAGPQG 50 HAGGQPGPEP 60 GAEEQPQAPE 70 QFEEAAAHST 80 PVRKEVTDKE 90 QEFAAAAAKQ 100 LEYQQFEDDK 110 LSQKSSSSKL 120 SRSPLKIVKK 130 PKSMQCKVIL 140 LDGSEYTCDV 150 EKRSRGQVLF 160 DKVCEHLNLL 170 EKDYFGLTYR 180 DAENQKNWLD 190 PAKEIKKQIR 200 SGAWHFSFNV 210 KFYPPDPAQL 220 SEDITRYYLC 230 LQLRDDIVSG 240 RLPCSFVTLA 250 LLGSYTVQSE 260 LGDYDPDECG 270 SDYVSEFRFA 280 PNHTKELEDK 290 VIELHKSHRG 300 MTPAEAEMHF 310 LENAKKLSMY 320 GVDLHHAKDS 330 EGVDIMLGVC 340 ASGLLIYRDR 350 LRINRFAWPK 360 VLKISYKRNN 370 FYIKIRPGEF 380 EQFESTIGFK 390 LPNHRAAKRL 400 WKVCVEHHTF 410 FRLLLPEAPP 420 KKFLTLGSKF 430 RYSGRTQAQT 440 RRASALIDRP 450 APYFERSSSK 460 RYTMSRSLDG 470 ASVNENHEMY 480 MKDSVSAAEV 490 GTGQYATTKG 500 ISQTNLITTV 510 TPEKKAEEER 520 DEEEERRKKA 530 EEATPVATVR 540 HEGKTDSERT 550 DTAADGETTA 560 TENSLIKRIK 570 GENVYVKHSN 580 LMLEELDKTQ 590 DDLMKHQTNI 600 SELKRTFLET 610 STDTAVTNEW 620 EKRLSTSPVR 630 LAARPEEAPM 640 IEPLVPEETK 650 QSSGEKLMDG 660 SEIFSLLESA 670 RKPTEFIGGV 680 TSTSQSWVQK 690 TETKTESSET 700 ETETTQRPQP 710 LSTETVVQET 720 VLVEERHVMS 730 VHASGDASST 740 AGDGVDAAAQ 750 AASAEASGVK 760 GKEGSALTEG 770 AKEDKGEVAD 780 RAVLEQEVMA 790 TASQEPEEER 800 LSAAIHVSET 810 LEQKPHFESS 820 TVKTETISFG 830 SVSPGGIKLE 840 ISTKEVPVVH 850 TETKTITYES 860 SQVDLGADLE 870 PGVLMSAQTI 880 TSETTSTTTT 890 THITRTVKGG 900 ISETRIEKRI 910 VITGDADIDH 920 DQALAQAIKE 930 AKEQHPDMSV 940 TKVVVHKETE ITPEDGED

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005938	cell cortex
Cellular Component	GO:0005856	cytoskeleton
Molecular Function	GO:0003779	actin binding
Molecular Function	GO:0005198	structural molecule activity
Biological Process	GO:0030866	cortical actin cytoskeleton organization

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.