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Overview

Uniprot IDA0A286ZL94
Protein NameSulfide:quinone oxidoreductase, mitochondrial
Gene NameSQOR
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
109 CIHTDNGKEISYRYL
130 QLDYEKIKGLPEGFD
155 RTVEKTWKALQDFKE
216 GAIFGVKKYADALQE

Function

Catalyzes the oxidation of hydrogen sulfide with the help of a quinone, such as ubiquinone-10, giving rise to thiosulfate and ultimately to sulfane (molecular sulfur) atoms. Requires an additional electron acceptor; can use sulfite, sulfide or cyanide (in vitro). It is believed the in vivo electron acceptor is glutathione

Protein Sequence

10 MLPYTQPYLF 20 LSSLIQPKDD 30 LTGHCGICGG 40 ITMAARMKRR 50 VGAENVAIVE 60 PSERHFYQPI 70 WTLVGAGIKQ 80 LSSSGRPTAS 90 VIPSGVEWIK 100 ARVVDLNPDK 110 NCIHTDNGKE 120 ISYRYLIIAL 130 GIQLDYEKIK 140 GLPEGFDHPK 150 IGSNYSFRTV 160 EKTWKALQDF 170 KEGNAIFTFP 180 NTPVKCAGAP 190 QKIMYLSEAY 200 FRKTGRRSKA 210 NIIFNTSLGA 220 IFGVKKYADA 230 LQEIIRERNL 240 TINYKQNLIE 250 VRADKQEAVF 260 ENLDKPGETQ 270 VISYEMLHVT 280 PPMSPPDVLK 290 TSPVADAAGW 300 VDVDKDTLQH 310 KRYPNVFGIG 320 DCTNLPTSKT 330 AAAVAAQSGV 340 LDRTISLIMK 350 NQTPTKKYDG 360 YTSCPLVTGY 370 NRVILAEFDY 380 NAKPLETFPF 390 DQSKERLSMY 400 LMKANMMPFL 410 YWNGMLRGYW 420 GGPAFLRKLF HLGMS

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005739 mitochondrion
Molecular Function GO:0106436 glutathione-dependent sulfide quinone oxidoreductase activity
Molecular Function GO:0048038 quinone binding
Molecular Function GO:0070224 sulfide:quinone oxidoreductase activity
Biological Process GO:0006790 sulfur compound metabolic process

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.