Search Results

Overview

Uniprot IDA0A286ZLB1
Protein NameHeat shock protein 75 kDa, mitochondrial
Gene NameTRAP1
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
322 YVAQAPDKPRYTLHY
367 SVSLYSRKVLIQTKA
411 QESALIRKLQGVLQQ
596 GSRVTNVKVTLRLDT
697 RLNRLLIKALERQPP
94 EFQAETKKLLDIVAR

Function

Chaperone that expresses an ATPase activity. Involved in maintaining mitochondrial function and polarization, downstream of PINK1 and mitochondrial complex I. Is a negative regulator of mitochondrial respiration able to modulate the balance between oxidative phosphorylation and aerobic glycolysis. The impact of TRAP1 on mitochondrial respiration is probably mediated by modulation of mitochondrial SRC and inhibition of SDHA

Protein Sequence

10 MARELRTLLL 20 WGHRLRAPAL 30 AAARGGNSVL 40 CPRRPPAQSW 50 HPRQCLASSF 60 HAGRPFSSQA 70 AEDRKEEPPH 80 CIISSSETVQ 90 GSVSKHEFQA 100 ETKKLLDIVA 110 RSLYSEKEVF 120 IRELISNASD 130 ALEKLRHKLV 140 SEGQTLPEME 150 IHLQTDSEKG 160 TITIQDTGVG 170 MTREELVSNL 180 GTIARSGSKA 190 FLDALQNQAE 200 ASGKIIGQFG 210 VGFYSAFMVA 220 DKVEVYSRSV 230 DAGSPGFQWL 240 SDGSGVFEIA 250 EAAGVRTGTK 260 IIIHLKADSR 270 EFAHEARVRD 280 VVTKYSNFVS 290 FPLYLNGRRL 300 NTLQAVWMMD 310 PKDVSEEQHE 320 EFYRYVAQAP 330 DKPRYTLHYK 340 TDAPLNIRSI 350 FYVPEMKPSV 360 FDVSRELGPS 370 VSLYSRKVLI 380 QTKATNILPT 390 WLRFVRGVVD 400 SEDIPLNLSR 410 ELLQESALIR 420 KLQGVLQQRL 430 IKFFSDQSKK 440 DVEKYARFFE 450 DYGLFMREGI 460 VTTTEQEVKE 470 DIAKLLRYES 480 SALPAGQLTS 490 LPDYASRMQA 500 GTRSIYYLCA 510 PNRHLAEHSP 520 YYEAMKQKNT 530 EVLFCYEQFD 540 ELTLLHLREF 550 DRKKLISVET 560 DIVIDHYKEE 570 KFEDSSPAGD 580 RLSEEEMEDL 590 MAWMRNALGS 600 RVTNVKVTLR 610 LDTHPAMITV 620 LEMGAARHFL 630 RMQQLAKTQE 640 ERAQLLQPTL 650 EINPRHTLIK 660 KLSQLRHSEP 670 DLAQLLVDQI 680 YENAMITAGL 690 SDDPRPMVSR 700 LNRLLIKALE 710 RQPPAELQAC 720 GTDTYSLLAQ 730 SECSLEVKGG 740 SGVGNHGTLE 750 QRPCDHDPTA 760 PDTGEVPPQP 770 TVCSVHLNLR 780 SQQVPQLISW 790 SGKCHKPTVP QLL

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005743 mitochondrial inner membrane
Cellular Component GO:0005759 mitochondrial matrix
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0016887 ATP hydrolysis activity
Molecular Function GO:0140662 ATP-dependent protein folding chaperone
Molecular Function GO:0019901 protein kinase binding
Molecular Function GO:0051082 unfolded protein binding
Biological Process GO:1901856 negative regulation of cellular respiration
Biological Process GO:0006457 protein folding
Biological Process GO:0009386 translational attenuation

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.