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Overview

Uniprot IDA0A286ZLE4
Protein NameCalnexin
Gene NameCANX
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
100 DTDDEIAKYDGKWEV
114 VDEMKETKLPGDKGL
119 ETKLPGDKGLVLLSR
135 KHHAISTKLNKPFIF
138 AISTKLNKPFIFDTK
171 AYVKLLSKTPELNLD
211 IFRHKNPKTGVYEEK
218 KTGVYEEKHAKRPDA
234 LKTYFTDKKTHLYTL
293 EDWDERPKIPDPDAV
508 LFCCSGKKQASPVEY
91 WILSKAKKDDTDDEI

Function

Calcium-binding protein that interacts with newly synthesized monoglucosylated glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor-mediated endocytosis at the synapse

Protein Sequence

10 MEGKWLLCML 20 LVLGTAVVQA 30 HDGHDDDVID 40 IEDDLDDVIE 50 EVEDSKPKPD 60 TSAPPSPKVT 70 YKAPVPTGEV 80 YFADSFDRGT 90 LSGWILSKAK 100 KDDTDDEIAK 110 YDGKWEVDEM 120 KETKLPGDKG 130 LVLLSRAKHH 140 AISTKLNKPF 150 IFDTKPLIVQ 160 YEVNFQNGIE 170 CGGAYVKLLS 180 KTPELNLDQF 190 HDKTPYTIMF 200 GPDKCGEDYK 210 LHFIFRHKNP 220 KTGVYEEKHA 230 KRPDADLKTY 240 FTDKKTHLYT 250 LILNPDNSFE 260 ILVDQAVVNS 270 GNLLNDMTPP 280 VNPSREIEDP 290 EDRKPEDWDE 300 RPKIPDPDAV 310 KPDDWDEDAP 320 AKIPDEEATK 330 PIGWLDDEPE 340 YVPDPDAEKP 350 EDWDEDMDGE 360 WEAPQIANPK 370 CESAPGCGVW 380 QRPMIDNPNY 390 KGKWKPPMID 400 NPNYQGIWKP 410 RKIPNPDFFE 420 DLEPFKMTPF 430 SAIGLELWSM 440 TSDIFFDNFI 450 ICGDRRVVDD 460 WANDGWGLKK 470 AADGAAEPGV 480 VGQMIEAAEE 490 RPWLWVVYIL 500 TVALPVFLVI 510 LFCCSGKKQA 520 SPVEYKKTDA 530 PQPDVKEEEE 540 EKEEEKEKGD 550 EEEEGEEKLG G

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005789 endoplasmic reticulum membrane
Cellular Component GO:0033162 melanosome membrane
Cellular Component GO:0031966 mitochondrial membrane
Molecular Function GO:0005509 calcium ion binding
Molecular Function GO:0030246 carbohydrate binding
Molecular Function GO:0051082 unfolded protein binding
Biological Process GO:0006457 protein folding

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.