Search Results
Overview
| Uniprot ID | A0A286ZLG6 |
|---|---|
| Protein Name | High mobility group protein HMG-I/HMG-Y |
| Gene Name | HMGA1 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 15 | SSQPLASKQEKDGTE |
| 31 | RGRGRPRKQPPVSPG |
| 46 | TALVGSQKEPSEVPT |
| 55 | PSEVPTPKRPRGRPK |
| 7 | *MSESSSKSSQPLAS |
| 74 | KGAAKTRKTTTAPGR |
Function
HMG-I/Y bind preferentially to the minor groove of A+T rich regions in double-stranded DNA. It is suggested that these proteins could function in nucleosome phasing and in the 3'-end processing of mRNA transcripts. They are also involved in the transcription regulation of genes containing, or in close proximity to A+T-rich regions
Protein Sequence
10
MSESSSKSSQ
20
PLASKQEKDG
30
TEKRGRGRPR
40
KQPPVSPGTA
50
LVGSQKEPSE
60
VPTPKRPRGR
70
PKGSKNKGAA
80
KTRKTTTAPG
90
RKPRGRPKKL
100
ARASLPPTCT
110
LTTTLHCTPA
120
RPTSPPAAAG
130
PRPKREAVFL
140
EEISVSGNPS
150
ATRATPAPAP
P
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0031965 | nuclear membrane |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0035985 | senescence-associated heterochromatin focus |
| Molecular Function | GO:0000987 | cis-regulatory region sequence-specific DNA binding |
| Molecular Function | GO:0019899 | enzyme binding |
| Molecular Function | GO:0003680 | minor groove of adenine-thymine-rich DNA binding |
| Molecular Function | GO:0140677 | molecular function activator activity |
| Molecular Function | GO:0046965 | nuclear retinoid X receptor binding |
| Molecular Function | GO:0042975 | peroxisome proliferator activated receptor binding |
| Molecular Function | GO:0003723 | RNA binding |
| Molecular Function | GO:0003713 | transcription coactivator activity |
| Molecular Function | GO:0001221 | transcription coregulator binding |
| Biological Process | GO:0006351 | DNA-templated transcription |
| Biological Process | GO:0008285 | negative regulation of cell population proliferation |
| Biological Process | GO:0045892 | negative regulation of DNA-templated transcription |
| Biological Process | GO:0090402 | oncogene-induced cell senescence |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.