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Overview

Uniprot ID	A0A286ZLR2
Protein Name	Serine/threonine-protein kinase DCLK1
Gene Name	DCLK1
Organism	Sus scrofa

Kla Sites from experimental identification

Position	Flanking peptide
170	VSSLATAKGSPSEVR
232	KLDSGVVKRLYTLDG
280	ESECRVVKSTSYTKI
286	VKSTSYTKIASSSRR

Function

Probable kinase that may be involved in a calcium-signaling pathway controlling neuronal migration in the developing brain. May also participate in functions of the mature nervous system

Protein Sequence

10 MSFGRDMELE 20 HFDERDKAQR 30 YSRGSRVNGL 40 PSPTHSAHCS 50 FYRTRTLQTL 60 SSEKKAKKVR 70 FYRNGDRYFK 80 GIVYAISPDR 90 FRSFEALLAD 100 LTRTLSDNVN 110 LPQGVRTIYT 120 IDGLKKISSL 130 DQLLEGESYV 140 CGSIEPFKKL 150 EYTKNVNPNW 160 SVNVKTTSAS 170 RAVSSLATAK 180 GSPSEVRENK 190 DFIRPKLVTI 200 IRSGVKPRKA 210 VRILLNKKTA 220 HSFEQVLTDI 230 TDAIKLDSGV 240 VKRLYTLDGK 250 QVMCLQDFFG 260 DDDIFIACGP 270 EKFRYQDDFL 280 LDESECRVVK 290 STSYTKIASS 300 SRRSTTKSPG 310 PSRRSKSPAS 320 TSSVNGTPGS 330 QLSTPRSGKS 340 PSPSPTSPGS 350 LRKQRSSQHG 360 GSSTSLASTK 370 VCSSMDENDG 380 PGEGEVSEEG 390 FQIPATITER 400 YKVGRTIGDG 410 NFAVVKECVE 420 RSTAREYALK 430 IIKKSKCRGK 440 EHMIQNEVSI 450 LRRVKHPNIV 460 LLIEEMDVPT 470 ELYLVMELVK 480 GGDLFDAITS 490 TNKYTERDAS 500 GMLYNLASAI 510 KYLHSLNIVH 520 RDIKPENLLV 530 YEHQDGSKSL 540 KLGDFGLATI 550 VDGPLYTVCG 560 TPTYVAPEII 570 AETGYGLKVD 580 IWAAGVITYI 590 LLCGFPPFRG 600 SGDDQEVLFD 610 QILMGQVDFP 620 SPYWDNVSDS 630 AKELITMMLL 640 VDVDQRFSAV 650 QVLEHPWVND 660 DGLPENEHQL 670 SVAGKIKKHF 680 NTGPKPNSTA 690 AGVSVIALDH 700 GFTIKRSGSL 710 DYYQQPGMYW 720 IRPPLLIRRG 730 RFSDEDATRM

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005737	cytoplasm
Molecular Function	GO:0005524	ATP binding
Molecular Function	GO:0004674	protein serine/threonine kinase activity
Biological Process	GO:0048675	axon extension
Biological Process	GO:0007417	central nervous system development
Biological Process	GO:0035556	intracellular signal transduction
Biological Process	GO:0009615	response to virus

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.