Search Results

Overview

Uniprot ID	A0A286ZM20
Protein Name	Serine/arginine repetitive matrix protein 1
Gene Name	SRRM1
Organism	Sus scrofa

Kla Sites from experimental identification

Position	Flanking peptide
36	KFAECLEKKVDMSKV

Function

Part of pre- and post-splicing multiprotein mRNP complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs. Involved in numerous pre-mRNA processing events. Promotes constitutive and exonic splicing enhancer (ESE)-dependent splicing activation by bridging together sequence-specific (SR family proteins, SFRS4, SFRS5 and TRA2B/SFRS10) and basal snRNP (SNRP70 and SNRPA1) factors of the spliceosome. Stimulates mRNA 3'-end cleavage independently of the formation of an exon junction complex. Binds both pre-mRNA and spliced mRNA 20-25 nt upstream of exon-exon junctions. Binds RNA and DNA with low sequence specificity and has similar preference for either double- or single-stranded nucleic acid substrates

Protein Sequence

10 MDAGFFRGTS 20 AEQDNRFSNK 30 QKKLLKQLKF 40 AECLEKKVDM 50 SKVNLEVIKP 60 WITKRVTEIL 70 GFEDDVVIEF 80 IFNQLEVKNP 90 DSKMMQINLT 100 GFLNGKNARE 110 FMGELWPLLL 120 SAQENIAGIP 130 SAFLELKKEE 140 IKQRQIEQEK 150 LASMKKQDED 160 KDKRDKEEKE 170 SSREKRERSR 180 SPRRRKSRSP 190 SPRRRSSPVR 200 RERKRSHSRS 210 PRHRTKSRSP 220 SPAPEKKEKT 230 PELPEPSVKV 240 KEPSVQEATS 250 TSDILKVPKP 260 EPVPEPKEPS 270 PEKNSKKEKE 280 KEKTRPRSRS 290 RSKSRSRTRS 300 RSPSHTRPRR 310 RHRSRSRSYS 320 PRRRPSPRRR 330 PSPRRRTPPR 340 RMPPPPRHRR 350 SRSPVRRRRR 360 SSASLSGSSS 370 SSSSSRSRSP 380 PKKAPKRTSS 390 PPRKTRRLSP 400 SASPPRRRHR 410 PSPPATPPPK 420 TRHSPTPQQS 430 NRTRKSRVSV 440 SPGRTSGKDS 450 GSSSSSEDER 460 PKRSHVKNGE 470 VGRRRRHTPS 480 RSASPSPRKR 490 QKETSPRGRR 500 RRSPSPPPTR 510 RRRSPSPAPP 520 PRRRRSPTPP 530 PRRRTPSPPP 540 RRRSPSPRRY 550 SPPIQRRYSP 560 SPPPKRRTAS 570 PPPPPKRRAS 580 PSPPPKRRVS 590 HSPPPKQRSS 600 PVTKRRSPSL 610 SSKHRKGPSP 620 SRSTREARSP 630 QPNKRHSPSP 640 RPRAPQTCSS 650 PPPARRGASS 660 SPQRRQSPSP 670 SSRPIRRVSR 680 TPEPKKTKKV 690 ASPSPQSVRR 700 VSSSRSVSGS 710 PEPAAKKPPA 720 PPSPVQSQSP 730 STNWSPAVPV 740 KKAKSPTPSP 750 SPARNSDPEG 760 GGKKKKKKKD 770 KKHKKDKKHK 780 KHKKHKKEKA 790 VAAAAAAAVT 800 PTAIAAPTTT 810 SAQEEPEAEP 820 EPKKETESEA 830 EDNLDDLEKH 840 LREKALRSMR KAQVSPQS

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005681	spliceosomal complex
Biological Process	GO:0006397	mRNA processing
Biological Process	GO:0008380	RNA splicing

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.