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Overview

Uniprot IDA0A286ZM64
Protein NameAfadin
Gene NameAFDN
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
1798 QGHEVSSKVKASRRL
663 SPAERTHKVIAIVNK

Function

Belongs to an adhesion system, probably together with the E-cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs). Nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton. May play a key role in the organization of epithelial structures of the embryonic ectoderm. Essential for the organization of adherens junctions

Protein Sequence

10 MSAGARDEER 20 RKLADIIQHW 30 NANRLDLFEI 40 SQPTEDLEFH 50 GVMRFYFQDK 60 AAGNFATKCI 70 RVSSTATTQD 80 VIETLAEKFR 90 PDMRMLSSPK 100 YSLYEVHVSG 110 EERRLDIDEK 120 PLVVQLNWNK 130 DDREGRFVLK 140 NENDAAPPKK 150 AQSNGPEKQE 160 KEGVIQNFKR 170 TLSKKEKKEK 180 KKREKEAMRQ 190 ASDKDDRPFH 200 GEDTENSRLA 210 AEVYKDMPET 220 SFTRTISNPE 230 VVMKRRRQQK 240 LEKRMQEFRS 250 SDGRPDSGGT 260 LRIYADSLKP 270 NIPYKTILLS 280 TTDPADFAVA 290 EALEKYGLEK 300 ENPKDYCIAR 310 VMLPPGAQHS 320 DEKGAKEIIL 330 DDDECPLQIF 340 REWPGDKGML 350 VFQLKRRPPE 360 HIPKKSKKHA 370 EGKPPKGKER 380 PDGSGYGSAL 390 PPEKLPYLVE 400 LSPGRRGHFA 410 YYSYHPHEDG 420 SDSRDKPKLY 430 RLQLSVTEVG 440 TEKFDDSSIQ 450 LFGSGIQPHH 460 CDLTNMDGVV 470 TVTPRSVDAE 480 TYVEGQRISE 490 TTMLQSGVKV 500 QFGASHVFKF 510 VDPSQDHALA 520 KRPGDGGLAV 530 KGPRHKPGIV 540 QETAFDLGGD 550 VHGGTAVASS 560 KGSARPDGDR 570 APSASSSAER 580 GMVKPMVRME 590 PPQEPRRQDT 600 RPQDAAGPEL 610 TLPASIEFRE 620 SAEDSFLSAI 630 INYTNSSTVH 640 FKLSPTYVLY 650 MACRHVLSSQ 660 YRPDVSPAER 670 THKVIAIVNK 680 MVSMMDGVIQ 690 EVDQVAEKQK 700 NIAGALAFWM 710 ANASELLNFI 720 KQDRDLSRIT 730 LDAQDVLAHL 740 VQMAFKYLVH 750 CLQSELNNYM 760 PAFLDDPEEN 770 SLQRPKIEDV 780 LHTLTGAMSL 790 LRRCRVNAAL 800 TIQLFSQLFH 810 FINMWLFNRL 820 LTDPESGLCS 830 HYWGAIVRQQ 840 LGHVEAWAEK 850 QGLELAADCH 860 LSRVVQATTL 870 LTMDKYAPED 880 AAGINSTCFK 890 LNSLQLQALL 900 HNYHCAPDEP 910 LVPPDLIESV 920 VAVAENTADE 930 LARSDGREVR 940 LEEDPDLQLP 950 FLLPEDGYSC 960 DVVRNIPNGL 970 QEFLDPLCQR 980 GFCRLTPQPR 990 SPGSWTIHFE 1000 GAEYESRLAR 1010 ESTELAQPLR 1020 KEPEVITVTL 1030 KKQNGMGLSI 1040 VAAKGAGQDK 1050 LGIYVKSVVR 1060 GGAADVDGRL 1070 AAGDQLLSVD 1080 GRSLVGLSQE 1090 RAAELMTRTS 1100 SVVTLEVAKQ 1110 GAIYHGLATL 1120 LNQPSPMMQR 1130 ISDRRGSGKP 1140 RPKSEGFELY 1150 NNSAQNGSPE 1160 SPPLPWAEYS 1170 EPKKLPGDER 1180 LTKNRADHRS 1190 SPNVANQPPS 1200 PGGKGAHAAG 1210 TAAKITSVST 1220 GNLCTEEQTP 1230 PPGTEAYPIP 1240 TQAYPREYFT 1250 FPASRSQDRV 1260 VPPQSQWPSY 1270 EEKPHADSSH 1280 SSLAVQRVTR 1290 SQEELREDAG 1300 AYPLHRMEAV 1310 MDRKSDSDMW 1320 VAQSSSMGSS 1330 ASSQEHLDPS 1340 SKAGTPASTL 1350 TKSGPGRWKT 1360 PAVLQPAPGP 1370 QPLRTDLPTH 1380 YAGDVDGVPV 1390 DLPLPPPPAA 1400 AGQGLAGGQG 1410 AAERKKREEQ 1420 QRWYEKEKAR 1430 LEEERERKRR 1440 EQERKLGQMR 1450 SQALLPAPLS 1460 PGATKPAAPG 1470 PQDTVIRELQ 1480 PQQQPRTIER 1490 RDLQYITVSR 1500 EELSAGDSLS 1510 PDPWKRDARE 1520 KLEKQQQMHV 1530 VDLLSREIHE 1540 LQSKAERSAE 1550 ESGRLRKLML 1560 EWQFQKRLQE 1570 SKQKDEDDDE 1580 EEDDDVDTML 1590 IMQRLEAERR 1600 ARQTAVPAIS 1610 VLDLLQDEER 1620 RRQQQLEEMR 1630 QREAEERARH 1640 EEERRRQEEE 1650 RLKREAEEKR 1660 RQEEGYYSRL 1670 EAERRRQHEE 1680 AERRLLEPEE 1690 PGLGRPPLPR 1700 GYEPPGPAPP 1710 PPPQRAASYL 1720 QAQVLSPDSL 1730 YTAKFVAYDD 1740 DDEEEDGPAG 1750 PASYMGSTGT 1760 LMGAHDGSRD 1770 PRETLSKSQD 1780 ADVPGGPESL 1790 TFRERQRLFS 1800 QGHEVSSKVK 1810 ASRRLTELEN ELNTK

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005912 adherens junction
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005886 plasma membrane
Molecular Function GO:0050839 cell adhesion molecule binding
Biological Process GO:0007155 cell adhesion
Biological Process GO:0030154 cell differentiation
Biological Process GO:0034330 cell junction organization
Biological Process GO:0032880 regulation of protein localization
Biological Process GO:0007165 signal transduction

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.