Search Results

Overview

Uniprot IDA0A286ZN32
Protein NameNuclear pore complex protein Nup153
Gene NameNUP153
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
1023 SVAPFTCKTPEAKKE
633 QNKVADNKCVACQAT
649 LPPRDTAKQLGTGTP
705 CVACETPKPGTGVKR

Function

Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with TPR, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Mediates TPR anchoring to the nuclear membrane at NPC. The repeat-containing domain may be involved in anchoring other components of the NPC to the pore membrane. Possible DNA-binding subunit of the nuclear pore complex (NPC)

Protein Sequence

10 MASGAGGLGG 20 GGGGKIRTRR 30 CHQGPIKPYQ 40 QGRQQHQGIL 50 SRVTESVKNI 60 VPGWLQRYFN 70 KNEDVCSCST 80 DTREVPQWPE 90 NREDDHTMYA 100 DEEGASVHDG 110 RITPEPTVSN 120 TEEPSTTSTA 130 SNYPDVLTRP 140 SLHRSHLNFS 150 MLESPALHCQ 160 PSTSSAFPIG 170 SSGFSLVKEI 180 KDSTSQHDDD 190 NISTTSGFSS 200 RASDKDIAVS 210 KNTSVPPLWS 220 PEAERSHSLS 230 QHTATSSKKP 240 AFNLSAFGTL 250 SPAPVRRQMK 260 AKQLNAQSYG 270 VTSSTARRIL 280 QSLEKMSSPL 290 ADAKRIPSVF 300 SSLNSSLDRS 310 GIDNTTDLQA 320 KRRKVDSQNP 330 PVQGLMTPKP 340 VSIAANRTVY 350 FKPSLTPSGE 360 LRKTNQRVDK 370 KHSTGYEKNM 380 SPGQNKERES 390 GFSYPNFSMS 400 AANGLSSGVG 410 SGGGKMRRER 420 TRFVASKPQD 430 EEEMEVPVLP 440 KISLPITSSS 450 LPTFNFSSSV 460 ITTSSPSPIS 470 PSQSLTNKVQ 480 MTSPNSTGSP 490 LFRFSSPIVK 500 STEADVLPPS 510 SIGFTFSVPV 520 AKTELSGSST 530 ISEPIMSSSA 540 EDITAVNNST 550 SCKKADEDGE 560 GLFRPAKTLK 570 EGSVLDVLKN 580 PGFTSPKADS 590 PAAQPTTTSP 600 IVYTRPAISS 610 SSSSGIGFGE 620 SLKAGPSWQC 630 DTCLLQNKVA 640 DNKCVACQAT 650 KLPPRDTAKQ 660 LGTGTPSKSG 670 KPTLSSPGTG 680 FGDKFKPAVG 690 TWDCDTCLVQ 700 NKPEAIKCVA 710 CETPKPGTGV 720 KRVFTLPVAS 730 ESAVTMAASS 740 SSCTVTTGAL 750 GFTDKFKRPM 760 GSWECPVCCV 770 SNNAEDNKCV 780 SCMSEKPGSS 790 VPASSSSTVP 800 VSVLSGGSLG 810 LDKFKKPEGN 820 WNCDVCLVEN 830 KADSTKCIAC 840 ESAKPGTKSE 850 FKGFGTSSSS 860 LNPATSSFKF 870 GIPSSSSAPS 880 QTLTNTGNFK 890 FGDQGGFKIG 900 VSSDLGSVNP 910 MSEEGFKFPK 920 PIGDFKFGVS 930 SDSKPEEVKK 940 DSKNDNNFKF 950 GLSSGLSNPA 960 PLAPFQFGVS 970 NLGQQEKKEE 980 VPESSSAGFS 990 FCSGVINPPP 1000 LAADTKVTSE 1010 SKNSFSFGTT 1020 DTKSVSVAPF 1030 TCKTPEAKKE 1040 ETPVTKGGFT 1050 FGSMDSAPLP 1060 SASFVLGRTE 1070 EKQQEPVTST 1080 SLVFGKKVDT 1090 EEPKCQPVFS 1100 FGNSEQTKDE 1110 GSSKSTFSFS 1120 TAKPSEKESE 1130 QPAKATFAFG 1140 AQTSTTADQG 1150 AAKPVFSFLN 1160 NNSSNSSTPA 1170 TSAGGGIFGS 1180 STTSSSAPVA 1190 AFVFGQASNP 1200 VSSSAFGNSA 1210 ESSTSQSLLF 1220 SQESKPATTS 1230 STGTAVTPFV 1240 FGPGPSSNNT 1250 ATSGFTFGAT 1260 TTSSSAGSSF 1270 VFGTGPSAPS 1280 ASPAFGANQT 1290 PTFGQSQGAS 1300 QPNPPGFGSI 1310 ASSAALFSAG 1320 SQPAPPTFGT 1330 VSSSSQPPVF 1340 GQQPSQSAFG 1350 SGTAPNSSSV 1360 FQFGSSTTNF 1370 NFTNNNPSGV 1380 FTFGANPSIP 1390 AASAQPSGSG 1400 GFPFNQSPGA 1410 FTVGSNGKNI 1420 FSSSGTSLSG 1430 RKIKTAVRRR K

Gene Ontology

Classification GO ID Description
Cellular Component GO:0042405 nuclear inclusion body
Cellular Component GO:0031965 nuclear membrane
Cellular Component GO:0034399 nuclear periphery
Cellular Component GO:0044615 nuclear pore nuclear basket
Molecular Function GO:0003677 DNA binding
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0051028 mRNA transport
Biological Process GO:0015031 protein transport

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.