Search Results
Overview
| Uniprot ID | A0A286ZNE7 |
|---|---|
| Protein Name | Squalene synthase |
| Gene Name | FDFT1 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 45 | SSLKTCYKYLNQTSR |
Function
Catalyzes the condensation of 2 farnesyl pyrophosphate (FPP) moieties to form squalene. Proceeds in two distinct steps. In the first half-reaction, two molecules of FPP react to form the stable presqualene diphosphate intermediate (PSQPP), with concomitant release of a proton and a molecule of inorganic diphosphate. In the second half-reaction, PSQPP undergoes heterolysis, isomerization, and reduction with NADPH or NADH to form squalene. It is the first committed enzyme of the sterol biosynthesis pathway
Protein Sequence
10
MEFVKCLGHP
20
EEFYNLLRFQ
30
MGGRRKVIPK
40
MNQDSLSSSL
50
KTCYKYLNQT
60
SRSFAAVIQA
70
LDGEMRHAVC
80
IFYLVLRALD
90
TLEDDMTISI
100
EKKIPLLHNF
110
HLHLYESDWR
120
FTESKEKDRQ
130
VLEDFPTIAL
140
EFRNLAEKYQ
150
VVIVDVCRKM
160
GFGMAEFLNK
170
HVTSEREWDK
180
YCHYVAGLVG
190
IGLSRLFSAS
200
ELEDPLVGED
210
TERANSMGLF
220
LQKTNIIRDY
230
LEDQQEGREF
240
WPQEVWSKYV
250
KKLGDFAKPE
260
NVDLAVQCLN
270
ELVTSTLHHI
280
PDVITYLSRL
290
RNQSIFNFCA
300
IPQVMAIATL
310
AACYNNQQVF
320
KGVVKIRKGQ
330
AVTLMMDATN
340
MPAVKAIIHQ
350
YMEEIYHRIP
360
DSDPYSAKTR
370
QIISTIRTQN
380
LPNCQLISRS
390
HYSPIYLSFV
400
MLLAALSWQY
410
LSTLSQVTED
YVQTGEH
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0098554 | cytoplasmic side of endoplasmic reticulum membrane |
| Cellular Component | GO:0005789 | endoplasmic reticulum membrane |
| Molecular Function | GO:0055056 | D-glucose transmembrane transporter activity |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:0051996 | squalene synthase [NAD(P)H] activity |
| Biological Process | GO:0006695 | cholesterol biosynthetic process |
| Biological Process | GO:0033489 | cholesterol biosynthetic process via desmosterol |
| Biological Process | GO:0033490 | cholesterol biosynthetic process via lathosterol |
| Biological Process | GO:0045338 | farnesyl diphosphate metabolic process |
| Biological Process | GO:0036197 | zymosterol biosynthetic process |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.