Search Results

Overview

Uniprot IDA0A286ZNJ7
Protein NameTranslocation protein SEC63 homolog
Gene NameSEC63
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
130 QYRLLSLKYHPDKGG
287 EIGSINLKKNEPPLT
535 KKKPLKKKSTPVPLS

Function

Mediates cotranslational and post-translational transport of certain precursor polypeptides across endoplasmic reticulum (ER). Proposed to play an auxiliary role in recognition of precursors with short and apolar signal peptides. May cooperate with SEC62 and HSPA5/BiP to facilitate targeting of small presecretory proteins into the SEC61 channel-forming translocon complex, triggering channel opening for polypeptide translocation to the ER lumen. Required for efficient PKD1/Polycystin-1 biogenesis and trafficking to the plasma membrane of the primary cilia

Protein Sequence

10 MAGQQFQYDD 20 SGNTFFYFLT 30 SFVGLIVIPA 40 TYYLWPRDQN 50 AEQNRLKNIR 60 KVYGRCMWYR 70 LRLLKPQPNI 80 IPTVKKIVLL 90 AGWALFLFLA 100 YKVSKTDREY 110 QEYNPYEVLN 120 LDPGATVAEI 130 KKQYRLLSLK 140 YHPDKGGDEV 150 MFMRIAKAYA 160 ALTDEESRKN 170 WEEFGNPDGP 180 QATSFGIALP 190 AWIVDQKNSI 200 LVLLVYGLAF 210 MVILPVVVGS 220 WWYRSIRYSG 230 DQILIRTTQI 240 YTYFVYKTRN 250 MDMKRLIMVL 260 AGASEFDPQY 270 NKDATSRPTD 280 NILIPQLIRE 290 IGSINLKKNE 300 PPLTCPYSLK 310 ARVLLLSHLA 320 RMKIPETLEE 330 DQQFMLKKCP 340 ALLQEMVNVI 350 CQLIIMARSR 360 EEREFRAPTL 370 ASLENCMKLS 380 QMAVQGLQQF 390 KSPLLQLPHI 400 EEDNLRRVSN 410 HKKYKIKTIQ 420 DLVSLKESDR 430 HNLLHFLEDE 440 KYEEVMAVLG 450 SFPYVTMDIK 460 SQVLDDEDSN 470 NITVGSLVTV 480 LVKLTRQTMA 490 EVFEKEQSIC 500 AAEEQPADDG 510 QGDTNKNRTK 520 GGWQQKSKGP 530 KKTAKSKKKK 540 PLKKKSTPVP 550 LSQPKQQKQK 560 QANGVVGSEA 570 AVKEDEEEVS 580 DKGSDSEEEE 590 TNRDSQSEKD 600 DGSDRDSDRE 610 QDEKQNKDDE 620 AEKQEWWWLY 630 IADRKEQTLI 640 SMPYHVCTLK 650 DTEEVELKFP 660 APGKPGNYQY 670 TVFLRSDSYM 680 GLDQIKPLKL 690 EVHEAKPVPE 700 NHPQWDTAIE 710 GDEDQEDSEG 720 FEDSFEEEEE EEEDDD

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005789 endoplasmic reticulum membrane
Biological Process GO:0006620 post-translational protein targeting to endoplasmic reticulum membrane
Biological Process GO:0015031 protein transport
Biological Process GO:0006614 SRP-dependent cotranslational protein targeting to membrane

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.