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Overview

Uniprot ID	A0A286ZNS2
Protein Name	Malic enzyme
Gene Name	ME2
Organism	Sus scrofa

Kla Sites from experimental identification

Position	Flanking peptide
225	GHIFRRPKGLFISIS

Function

NAD-dependent mitochondrial malic enzyme that catalyzes the oxidative decarboxylation of malate to pyruvate

Protein Sequence

10 MGAGAGLLSP 20 GQGSRLRTRC 30 RLPRVRPSRS 40 PLRGWEGGVN 50 GRERKRLTES 60 RLRTGAAGRM 70 AATLSSAVGG 80 SSLALRDATS 90 QSRAPSFRLV 100 VREMMLSRFK 110 IVATPCTLAC 120 RHLHIKEKGK 130 PLMLNPRTNK 140 GMAFTLQERQ 150 MLGLQGLLPP 160 KIETQDIQAL 170 RFHRNVKKLN 180 GPLEKYIYIM 190 GIQERNEKLF 200 YRILQDDIET 210 LMPIVYTPTV 220 GLACSQYGHI 230 FRRPKGLFIS 240 ISDRGHVRSI 250 VDNWPENHVK 260 AVVVTDGERI 270 LGLGDLGVYG 280 MGIPVGKLCL 290 YTACAGIRPD 300 RCLPVCIDVG 310 TDNPALLKDP 320 FYMGLYQKRD 330 RSQRYDDLID 340 EFMKAITDRY 350 GRNILIQFED 360 FGNHNAFRFL 370 RKYREKYCTF 380 NDDIQGTAAV 390 ALAGLLAAQK 400 VIGKSISEHK 410 ILFLGAGEAA 420 LGIANLIVMA 430 MVENGLSEEE 440 AQKKIWMVDK 450 FGLLFKGRKA 460 KIDSHQEPFA 470 HPAPDNIPDN 480 FEDAVNILKP 490 SAIIGVAGAG 500 RLFTHNVIKA 510 MADINERPII 520 FALSNPTAQA 530 ECTAEEAYTL 540 TEGRCLFASG 550 SPFGPVKLSD 560 GQVFTPGQGN 570 NVYIFPGVAL 580 AVILCNTRHI 590 SDHVFLEAAK 600 ALTSQLTDKE 610 LAQGRLYPPL 620 ANIQEVSINI 630 AIKVTEYLYA 640 NKMAFRYPEP 650 EDKARYIRER 660 IWRSEYDSLL 670 PDVYEWPESA SHPPQITE

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005759	mitochondrial matrix
Cellular Component	GO:0005739	mitochondrion
Molecular Function	GO:0004471	malate dehydrogenase (decarboxylating) (NAD+) activity
Molecular Function	GO:0004473	malate dehydrogenase (decarboxylating) (NADP+) activity
Molecular Function	GO:0046872	metal ion binding
Molecular Function	GO:0051287	NAD binding
Biological Process	GO:0006108	malate metabolic process
Biological Process	GO:1902031	regulation of NADP metabolic process

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.