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Overview

Uniprot ID	A0A286ZP90
Protein Name	CLIP-associating protein 1
Gene Name	CLASP1
Organism	Sus scrofa

Kla Sites from experimental identification

Position	Flanking peptide
456	ITSNCTSKSVAVRRR

Function

Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle

Protein Sequence

10 MEPRMEACLA 20 QVLQKDVGKR 30 LQVGQELIDY 40 FSDKQKSADL 50 EHDQTMLDKL 60 VDGLATSWVN 70 SSNYKVALLG 80 MDILSALVTR 90 LQDRFKAQIG 100 TVLPSLIDRL 110 GDAKDSVREQ 120 DQTLLLKIMD 130 QAANPQYVWD 140 RMLGGFKHKN 150 FRTREGTCLC 160 LVATLNASGA 170 HTLTLSKIVP 180 HICNLLGDPN 190 SQVRDAAINS 200 LVEIYRHVGE 210 RVRADLSKKG 220 LPQSRLNVIF 230 TKFDEVQKSG 240 NMVQSANDKN 250 FDDEDSVDGN 260 RPSSASSTSS 270 KAPPSSRRNV 280 GMGTTRRLGS 290 STVGSKSSAA 300 KEGAGAVDEE 310 DFIKAFDDVP 320 VVQIYSSRDL 330 EESINKIREI 340 LSDDKHDWEQ 350 RVNALKKIRS 360 LLLAGAAEYD 370 NFFQHLRLLD 380 GAFKLSAKDL 390 RSQVVREACI 400 TLGHLSSVLG 410 NKFDHGAEAI 420 MPTIFNLIPN 430 SAKIMATSGV 440 VAVRLIIRHT 450 HIPRLIPVIT 460 SNCTSKSVAV 470 RRRCFEFLDL 480 LLQEWQTHSL 490 ERHISVLAET 500 IKKGIHDADS 510 EARIEARKCY 520 WGFHSHFSRE 530 AEHLYHTLES 540 SYQKALQSHL 550 KNSDSIASLP 560 QSDRSSSSSQ 570 ESLNRPLSAK 580 RSPTGSTTSR 590 ASTVSTKSVS 600 TTGSLQRSRS 610 DIDVNAAASA 620 KSKVTSTPGT 630 TPFSSAAALP 640 PGSYASLESR 650 PMREDAESVG 660 LDSGRIRTRR 670 QSSGSATNVA 680 STPSDSRGRS 690 RAKVVSQSQP 700 GSRSSSPGKL 710 LGSGYSGLAG 720 SSSRGPPVTP 730 SSEKRSKIPR 740 SQGCSRETSP 750 SRIGLDRFGL 760 GQAGRIPGSV 770 NAMRVLSTST 780 DLEAAVADAL 790 LLGDSRSKKP 800 VRRRYEPYGM 810 YSDDDANSDA 820 SSVCSERSYG 830 SRNGGIPHYL 840 RQTEDVAEVL 850 NHCASSNWSE 860 RKEGLLGLQN 870 LLKSQRTLSR 880 VELKRLCEIF 890 TRMFADPHSK 900 RVFSMFLETL 910 VDFIIIHKDD 920 LQDWLFVLLT 930 QLLKKMGADL 940 LGSVQAKVQK 950 ALDVTRDSFP 960 FDQQFNILMR 970 FIVDQTQTPN 980 LKVKVAILKY 990 IESLARQMDP 1000 TDFVNSSETR 1010 LAVSRIITWT 1020 TEPKSSDVRK 1030 AAQIVLISLF 1040 ELNTPEFTML 1050 LGALPKTFQD 1060 GATKLLHNHL 1070 KNSSNTSVGS 1080 PSNTIGRTPS 1090 RHTSSRTSPL 1100 TSPTNCSHGG 1110 LSPSMLDYDT 1120 ENLNSEEIYS 1130 SLRGVTEAIE 1140 KFSFRSQEDL 1150 NEPIKRDGRK 1160 DCEIVPRDGG 1170 VASPATEGRG 1180 GSDVVAGGRT 1190 ALDNKTSLLN 1200 TQPPRAFPGP 1210 RARDYSPYPY 1220 CDAISAYDKT 1230 ALQEAVFDDD 1240 MEQLRDVPID 1250 HSDLVADLLK 1260 ELSNHNERVE 1270 ERKGALLELL 1280 KVTREDSLGV 1290 WEEHFKTILL 1300 LLLETLGDKD 1310 HSIRALALRV 1320 LREILRNQPA 1330 RFKNYAELTI 1340 MKTLEAHKDS 1350 HKEVVRAAEE 1360 AASTLASSIH 1370 PEQCIKVLCP 1380 IIQTADYPIN 1390 LAAIKMQTKV 1400 VERIAKESLL 1410 QLLADIIPGL 1420 LQGYDNTESS 1430 VRKASVFCLV 1440 AIYSVIGEEL 1450 KPHLAQLTGS 1460 KMKLLNLYIK 1470 RAQTTNSNSS SSSDVSTHS

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005813	centrosome
Cellular Component	GO:0005794	Golgi apparatus
Cellular Component	GO:0000776	kinetochore
Cellular Component	GO:0005874	microtubule
Cellular Component	GO:0005819	spindle
Molecular Function	GO:0008017	microtubule binding
Biological Process	GO:0051301	cell division
Biological Process	GO:0030010	establishment of cell polarity
Biological Process	GO:0007026	negative regulation of microtubule depolymerization

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.