Overview
| Uniprot ID | A0A286ZPA4 |
|---|
| Protein Name | Polypyrimidine tract-binding protein 1 |
|---|
| Gene Name | PTBP1 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 104 |
YIQFSNHKELKTDSS |
| 107 |
FSNHKELKTDSSPNQ |
| 229 |
TLRIDFSKLTSLNVK |
| 236 |
KLTSLNVKYNNDKSR |
| 355 |
YGDVQRVKILFNKKE |
| 397 |
PVRITLSKHQNVQLP |
| 415 |
QEDQGLTKDYGNSPL |
| 472 |
GGIVKGFKFFQKDRK |
Function
Plays a role in pre-mRNA splicing and in the regulation of alternative splicing events. Activates exon skipping of its own pre-mRNA during muscle cell differentiation. Binds to the polypyrimidine tract of introns. May promote RNA looping when bound to two separate polypyrimidine tracts in the same pre-mRNA. May promote the binding of U2 snRNP to pre-mRNA. Cooperates with RAVER1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA. Represses the splicing of MAPT/Tau exon 10. Binds to polypyrimidine-rich controlling element (PCE) of CFTR and promotes exon skipping of CFTR exon 9, thereby antagonizing TIA1 and its role in exon inclusion of CFTR exon 9. Plays a role in the splicing of pyruvate kinase PKM by binding repressively to a polypyrimidine tract flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform
Protein Sequence
10
MSSNSASTAN
20
GNDSKKFKGD
30
NRSAGVPSRV
40
IHIRKLPSDV
50
TEGEVISLGL
60
PFGKVTNLLM
70
LKGKNQAFIE
80
MNTEEAANTM
90
VNYYTSVTPV
100
LRGQPIYIQF
110
SNHKELKTDS
120
SPNQARAQAA
130
LQAVNSVQSG
140
NLALAASAAA
150
VDAGMAMAGQ
160
SPVLRIIVEN
170
LFYPVTLDVL
180
HQIFSKFGTV
190
LKIITFTKNN
200
QFQALLQYAD
210
PVSAQHAKLS
220
LDGQNIYNAC
230
CTLRIDFSKL
240
TSLNVKYNND
250
KSRDYTRPDL
260
PSGDNQPSLD
270
QTMAAAFGAP
280
GIMSASPYAG
290
AGFPPTFAIP
300
QAAGLSVPNV
310
HGALAPLAIP
320
SAAAAAAAAG
330
RIAIPGLAGA
340
GNSVLLVSNL
350
NPEVRGVYGD
360
VQRVKILFNK
370
KENALVQMAD
380
GSQAQLAMSH
390
LNGHKLHGKP
400
VRITLSKHQN
410
VQLPREGQED
420
QGLTKDYGNS
430
PLHRFKKPGS
440
KNFQNIFPPS
450
ATLHLSNIPP
460
SISEEDLKIL
470
FSSNGGIVKG
480
FKFFQKDRKM
490
ALIQMGSVEE
500
AIQALIDLHN
510
HDLGENHHLR
VSFSKSTI
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005634 |
nucleus |
| Molecular Function |
GO:0003723 |
RNA binding |
| Biological Process |
GO:0006397 |
mRNA processing |
| Biological Process |
GO:0010629 |
negative regulation of gene expression |
| Biological Process |
GO:1903312 |
negative regulation of mRNA metabolic process |
| Biological Process |
GO:0008380 |
RNA splicing |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.