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Overview

Uniprot IDA0A286ZPB7
Protein NameUbiquitin carboxyl-terminal hydrolase 16
Gene NameUSP16
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
319 EEHQRVSKGILKAFG

Function

Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes

Protein Sequence

10 MGKKRTKGKT 20 VPIDDSSESL 30 EPTCRHIRKG 40 LEQGNLKKAL 50 VNVEWNICQD 60 CKTDNKVKDK 70 SEEETENPSV 80 WLCLKCGHQG 90 CGRDSQEQHA 100 LKHYMTPRSE 110 PHCLVLSLDN 120 WSVWCYLCDD 130 EVQYCNSNRL 140 GQVVDYVRKQ 150 AGITAPKSAK 160 DNGNIELENK 170 KLEKESKNEQ 180 EREKKENKAK 190 ENPSMNSASQ 200 ITVKGLSNLG 210 NTCFFNAVMQ 220 NLSQTPVLRE 230 LLKEVKMSGT 240 IVKIEPPDLA 250 LTEPLEINLE 260 PPGPLTLAMS 270 QFLNEMQETK 280 KGIVTPRELF 290 SQVCKKAVRF 300 KGYQQQDSQE 310 LLRYLLDGMR 320 AEEHQRVSKG 330 ILKAFGNSTE 340 KLDEELKNKV 350 KDYEKKKSVP 360 SFVDRIFGGE 370 LTSTIMCDEC 380 RTVSLVHESF 390 LDLSLPVLDD 400 QSGKKSINDK 410 NLKKTMEDED 420 KDCEEEKDND 430 SYIKERNDIP 440 SGTSKHLQKK 450 AKKQAKKQAK 460 YQRRQQKIQG 470 KVLHLNDVCA 480 VDHPEDNECE 490 VEASTSEVDV 500 KSSHTSQEEV 510 MHKECCEKDL 520 NGHEKTVESV 530 TDNQKSTEEG 540 DMKIVNLDND 550 LEVLASSPTE 560 CTGNLNGAYL 570 KAGSNGEVDI 580 SSGFKNLNLN 590 AALEPDEINI 600 EILNDDLTPG 610 AKVYEVVNED 620 PETAFCTLAN 630 REAFNTDECS 640 IQHCLYQFTR 650 NEKLRDANKL 660 LCEVCTRRQY 670 SGPKANIKGE 680 RKHVYTNAKK 690 QMLISLAPPV 700 LTLHLKRFQQ 710 AGFNLRKVNK 720 HIKFPEILDL 730 APFCTLKCKN 740 VAEENTRVLY 750 SLYGVVEHSG 760 TMRSGHYTAY 770 AKARTANSHL 780 SDLVLHGDIP 790 QDFEMESTKG 800 QWFHISDTHV 810 QAVPTTKVLN 820 SQAYLLFYER IL

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0004843 cysteine-type deubiquitinase activity
Molecular Function GO:0004197 cysteine-type endopeptidase activity
Molecular Function GO:0042393 histone binding
Molecular Function GO:0140950 histone H2A deubiquitinase activity
Molecular Function GO:0043024 ribosomal small subunit binding
Molecular Function GO:0003713 transcription coactivator activity
Molecular Function GO:0043130 ubiquitin binding
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0051301 cell division
Biological Process GO:0006974 DNA damage response
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0140014 mitotic nuclear division
Biological Process GO:0035520 monoubiquitinated protein deubiquitination
Biological Process GO:0045893 positive regulation of DNA-templated transcription
Biological Process GO:0090070 positive regulation of ribosome biogenesis
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0045901 positive regulation of translational elongation
Biological Process GO:0051289 protein homotetramerization
Biological Process GO:0006508 proteolysis
Biological Process GO:0051726 regulation of cell cycle

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.