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Overview

Uniprot ID	A0A286ZPR5
Protein Name	Eukaryotic translation initiation factor 2A
Gene Name	EIF2A
Organism	Sus scrofa

Kla Sites from experimental identification

Position	Flanking peptide
167	AVYVPGSKGAPSFVR
325	VWDVKNYKLISKPVA

Function

Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner

Protein Sequence

10 MAPSAPLLTV 20 RGSEGLYLVN 30 GPPHFTESTV 40 FPRINVINVT 50 TKELLHSFDL 60 PKAVCLEFSP 70 KNTILATWQP 80 YTTSKDGAAG 90 IPNLQLYDMK 100 TGTCLKSFIQ 110 KKMQNWCPSW 120 SEDETLCARN 130 VNNEVHFFEN 140 NNFNTIANKL 150 HLKKINDFVL 160 SPGPQPYKVA 170 VYVPGSKGAP 180 SFVRLYQYPN 190 FDGPHAALAN 200 KSFFKADKVT 210 MLWNKKATAV 220 LVIASTEVDK 230 TGASYYGEQT 240 LHYIATNGES 250 AVVQLPKNGP 260 IYDVVWNSSS 270 TEFCAVYGFM 280 PAKATIFNLK 290 CDPVFDFGTG 300 PRNAAYYSPH 310 GHILVLAGFG 320 NLRGQMEVWD 330 VKNYKLISKP 340 VASDSTYFAW 350 CPDGEHILTA 360 TCAPRLRVNN 370 GYKIWHYTGS 380 VLHKYDVPSN 390 AELWQVSWQP 400 FLDGIFPEKS 410 ITYQAVPSDV 420 PSEEPKVATA 430 YRPPALRNKP 440 VTNSKLHEEE 450 PPQNMKPQPG 460 NEKPLSKTAL 470 KNQRKHEAKK 480 AAKQEARSDK 490 SPDMAPSPAP 500 QNTPRNTVSH 510 STSGDPEIDK 520 KIKNLKKKLK 530 AIEQLKEQAA 540 TGKQLEKNQL 550 EKIQKEKALL 560 QELEDLELGI

Gene Ontology

Classification	GO ID	Description
Molecular Function	GO:0043022	ribosome binding
Molecular Function	GO:0003743	translation initiation factor activity
Molecular Function	GO:0000049	tRNA binding
Biological Process	GO:0006417	regulation of translation

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.