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Overview

Uniprot IDA0A286ZPT0
Protein NameCoatomer subunit beta'
Gene NameCOPB2
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
129 IKLWDWDKKWSCSQV
167 ASLDRTIKVWQLGSS
211 GADDRLVKIWDYQNK
317 NGKIIWAKHSEVQQA
412 RESNSVVKIFKNFKE
626 RVAHFLEKQGFKQQA
670 AESEQKWKQLAELAI
778 LWRENLSKVNQKAAE
821 HADLWPAKQYPLVTP

Function

The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors

Protein Sequence

10 PLRLDIKRKL 20 TARSDRVKSV 30 DLHPTEPWML 40 ASLYNGSVCV 50 WNHETQTLVK 60 TFEVCDLPVR 70 AAKFVARKNW 80 VVTGADDMQI 90 RVFNYNTLER 100 VHMFEAHSDY 110 IRCIAVHPTQ 120 PFILTSSDDM 130 LIKLWDWDKK 140 WSCSQVFEGH 150 THYVMQIVIN 160 PKDNNQFASA 170 SLDRTIKVWQ 180 LGSSSPNFTL 190 EGHEKGVNCI 200 DYYSGGDKPY 210 LISGADDRLV 220 KIWDYQNKTC 230 VQTLEGHAQN 240 VSCASFHPEL 250 PIIITGSEDG 260 TVRIWHSSTY 270 RLESTLNYGM 280 ERVWCVASLR 290 GSNNVALGYD 300 EGSIIVKLGR 310 EEPAMSMDAN 320 GKIIWAKHSE 330 VQQANLKAMG 340 DAEIKDGERL 350 PLAVKDMGSC 360 EIYPQTIQHN 370 PNGRFVVVCG 380 DGEYIIYTAM 390 ALRNKSFGSA 400 QEFAWAHDSS 410 EYAIRESNSV 420 VKIFKNFKEK 430 KSFKPDFGAE 440 SIYGGFLLGV 450 RSVNGLAFYD 460 WDNTELIRRI 470 EIQPKHIFWS 480 DSGELVCIAT 490 EESFFILKYL 500 SEKVLAAQET 510 HEGVTEDGIE 520 DGFEVLGEIQ 530 EIVKTGLWVG 540 DCFIYTSSVN 550 RLNYYVGGEI 560 VTIAHLDRTM 570 YLLGYIPKDN 580 RLYLGDKELN 590 IVSYSLLVSV 600 LEYQTAVMRR 610 DFSMADKVLP 620 TIPKEQRTRV 630 AHFLEKQGFK 640 QQALTVSTDP 650 EHRFELALQL 660 GELKIAYQLA 670 VEAESEQKWK 680 QLAELAISKC 690 QFGLAQECLH 700 HAQDYGGLLL 710 LATASGNASM 720 VNKLAEGAER 730 DGKNNVAFMS 740 YFLQGKLDAC 750 LELLIRTGRL 760 PEAAFLARTY 770 LPSQVSRVVK 780 LWRENLSKVN 790 QKAAESLADP 800 TEYENLFPGL 810 KEAFVVEEWV 820 KETHADLWPA 830 KQYPLVTPNE 840 ERNVMEEAKG 850 FQPSRSAAQQ 860 ELAGKPASPT 870 PVIMATHTGN 880 KEEKQSLLEL 890 EVDLDNLELE 900 DIDTTDINLD EDILDD

Gene Ontology

Classification GO ID Description
Cellular Component GO:0030126 COPI vesicle coat
Cellular Component GO:0000139 Golgi membrane
Molecular Function GO:0005198 structural molecule activity
Biological Process GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport
Biological Process GO:0006891 intra-Golgi vesicle-mediated transport
Biological Process GO:0006886 intracellular protein transport
Biological Process GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.