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Overview

Uniprot ID	A0A286ZQ47
Protein Name	ATP-dependent 6-phosphofructokinase
Gene Name	PFKM
Organism	Sus scrofa

Kla Sites from experimental identification

Position	Flanking peptide
707	FDRNFATKMGAKAMN

Function

Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis

Protein Sequence

10 MIPLAFYGYK 20 SMFSFERDKP 30 KRQKYEEWIM 40 THEEHHAAKS 50 LGVGKAIAVL 60 TSGGDAQGMN 70 AAVRAVVRVG 80 IYTGARVFFV 90 HEGYQGLVDG 100 GDNIREATWE 110 SVSMMLQLGG 120 TVIGSARCKD 130 FREREGRLRA 140 AHNLVKRGIT 150 NLCVIGGDGS 160 LTGADTFRSE 170 WGDLLNDLQK 180 AGKITAEEAN 190 KSSYLNIVGL 200 VGSIDNDFCG 210 TDMTIGTDSA 220 LHRIIEIVDA 230 ITTTAQSHQR 240 TFVLEVMGRH 250 CGYLALVTSL 260 SCGADWVFIP 270 ECPPDDAWEE 280 HLCRRLSETR 290 TRGSRLNIII 300 VAEGAIDKNG 310 QPITSENIKD 320 LVVKRLGYDT 330 RVTVLGHVQR 340 GGTPSAFDRI 350 LGSRMGVEAV 360 MALLEGTPDT 370 PACVVSLSGN 380 QAVRLPLMEC 390 VQVTKDVTKA 400 MNEKRFDEAM 410 KLRGRSFMNN 420 WEVYKLLAHV 430 RPPVTKSGSY 440 TVAVMNVGAP 450 AAGMNAAVRS 460 TVRIGLIQGN 470 RVLVVHDGFE 480 GLAKGQIEEA 490 GWSYVGGWTG 500 QGGSKLGTKR 510 TLPKKSFEQI 520 SANITKFNIQ 530 GLVIIGGFEA 540 YTGGLELMEG 550 RKQYDELCIP 560 FVVIPATVSN 570 NVPGSDFSVG 580 ADTALNTICM 590 TCDRIKQSAA 600 GTKRRVFIIE 610 TMGGYCGYLA 620 TMAGLAAGAD 630 AAYIFEEPFT 640 IRDLQVNVEH 650 LVQKMKTTVK 660 RGLVLRNEKC 670 NENYTTDFIF 680 NLYSEEGKGI 690 FDSRKNVLGH 700 MQQGGSPTPF 710 DRNFATKMGA 720 KAMNWMSGKI 730 KESYRNGRIF 740 ANTPDSGCVL 750 GMRKRALVFQ 760 PVTELKEQTD 770 FEHRIPKEQW 780 WLKLRPILKI 790 LAKYEIDLDT 800 SEHAHLEHIT RKRSGEATI

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005737	cytoplasm
Molecular Function	GO:0003872	6-phosphofructokinase activity
Molecular Function	GO:0005524	ATP binding
Molecular Function	GO:0046872	metal ion binding
Biological Process	GO:0006002	fructose 6-phosphate metabolic process

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.