Search Results
Overview
| Uniprot ID | A0A286ZQY6 |
|---|---|
| Protein Name | Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial |
| Gene Name | IDH3A |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 153 | LITEGASKRIAEFAF |
| 199 | REVAENCKDIKFNEM |
| 306 | TACFATIKDGKSLTK |
| 313 | KDGKSLTKDLGGNAK |
| 34 | MKIFDAAKAPIQWEE |
Function
Catalytic subunit of the enzyme which catalyzes the decarboxylation of isocitrate (ICT) into alpha-ketoglutarate. The heterodimer composed of the alpha (IDH3A) and beta (IDH3B) subunits and the heterodimer composed of the alpha (IDH3A) and gamma (IDH3G) subunits, have considerable basal activity but the full activity of the heterotetramer (containing two subunits of IDH3A, one of IDH3B and one of IDH3G) requires the assembly and cooperative function of both heterodimers
Protein Sequence
10
MLSYIQVKTV
20
TLIPGDGIGP
30
EISAAVMKIF
40
DAAKAPIQWE
50
ERNVTAIQGP
60
GGKWMIPPEA
70
KESMDKNKMG
80
LKGPLKTPIA
90
AGHPSMNLLL
100
RKTFDLYANV
110
RPCVSIEGYK
120
TPYTDVNIVT
130
IRENTEGEYS
140
GIEHVIVDGV
150
VQSIKLITEG
160
ASKRIAEFAF
170
EYARNNHRSN
180
VTAVHKANIM
190
RMSDGLFLQK
200
CREVAENCKD
210
IKFNEMYLDT
220
VCLNMFYLSK
230
YPLTCFPVPS
240
DLCAGLIGGL
250
GVTPSGNIGA
260
NGVAIFESVH
270
GTAPDIAGKD
280
MANPTALLLS
290
AVMMLRHMGL
300
FDHAAKIETA
310
CFATIKDGKS
320
LTKDLGGNAK
330
CSDFTEEICR
RVKDLD
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Molecular Function | GO:0004449 | isocitrate dehydrogenase (NAD+) activity |
| Molecular Function | GO:0046872 | metal ion binding |
| Biological Process | GO:0006099 | tricarboxylic acid cycle |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.