Overview
| Uniprot ID | A0A286ZQZ3 |
|---|
| Protein Name | - |
|---|
| Gene Name | COPS7A |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 86 |
SVVTLAAKVKCIPYA |
Function
Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively
Protein Sequence
10
MSAEVKVTGQ
20
NQEQFLLLAK
30
SAKGAALATL
40
IHQLAESDFA
50
STFRLLTVFA
60
YGTYADYLAE
70
ARNLPPLTEA
80
QKNKLRHLSV
90
VTLAAKVKCI
100
PYAVLLEALA
110
LRNVRQLEDL
120
VIEAVYADVL
130
RGSLDQRNQR
140
LEVDYSIGRD
150
IQRQDLSAIA
160
RTLQEWCVGC
170
EVVLSGIEEQ
180
VSRANQHKEQ
190
QLGLKQQIES
200
EVANLKKTIK
210
VTTAAAAAAT
220
SQDPEQHLTE
230
LREPAPGTNQ
240
RQPSKKASKG
250
KGHCVDPFSH
260
CVDPLTLALH
LQQPVKQA
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0008180 |
COP9 signalosome |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Biological Process |
GO:0010387 |
COP9 signalosome assembly |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.