Overview
| Uniprot ID | A0A286ZRL8 |
|---|
| Protein Name | Nucleolar protein 58 |
|---|
| Gene Name | NOP58 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 210 |
TYCKCLQKVGDRKNY |
| 323 |
VQILGAEKALFRALK |
| 37 |
KEFETPEKANKVVKL |
| 411 |
RKISGTGKALAKAEK |
| 441 |
STLPTFSKKRRIEQV |
| 81 |
KVLKKIVKEAHEPLA |
| 93 |
PLAVADAKLGGVIKE |
| 99 |
AKLGGVIKEKLNLSC |
Function
Required for the biogenesis of box C/D snoRNAs such as U3, U8 and U14 snoRNAs. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) complexes that function in methylation of multiple sites on ribosomal RNAs (rRNAs) and messenger RNAs (mRNAs)
Protein Sequence
10
MLVLFETSVG
20
YAIFKVLNEK
30
KLQEVDSLWK
40
EFETPEKANK
50
VVKLKHFEKF
60
QDTAEALAAF
70
TALMEGKINK
80
QLKKVLKKIV
90
KEAHEPLAVA
100
DAKLGGVIKE
110
KLNLSCIHSP
120
VVNELMRGIR
130
SQMDGLIPGV
140
EPREMAAMCL
150
GLAHSLSRYR
160
LKFSADKVDT
170
MIVQAISLLD
180
DLDKELNNYI
190
MRCREWYGWH
200
FPELGKIISD
210
NLTYCKCLQK
220
VGDRKNYASA
230
KLSELLPEEV
240
EAEVKAAAEI
250
SMGTEVSEED
260
ICNILHLCTQ
270
VIEISEYRTQ
280
LYEYLQNRMM
290
AIAPNVTVMV
300
GELVGARLIA
310
HAGSLLNLAK
320
HAASTVQILG
330
AEKALFRALK
340
SRRDTPKYGL
350
IYHASLVGQT
360
SPKHKGKISR
370
MLAAKTVLAI
380
RYDAFGEDSS
390
SAMGVENRAK
400
LEARLRTLED
410
RGIRKISGTG
420
KALAKAEKYE
430
HKSEVKTYDP
440
SGDSTLPTFS
450
KKRRIEQVDK
460
EDEVIEKKAK
470
KAKVKIKALL
480
VCEHLGKPTV
490
SQAFVKWMTR
500
KTQGDKIQQL
510
LPSGSLQSEL
QTS
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0031428 |
box C/D methylation guide snoRNP complex |
| Cellular Component |
GO:0032040 |
small-subunit processome |
| Molecular Function |
GO:0030515 |
snoRNA binding |
| Biological Process |
GO:0042254 |
ribosome biogenesis |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.