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Overview

Uniprot ID	A0A286ZRT5
Protein Name	Mitochondrial-processing peptidase subunit alpha
Gene Name	PMPCA
Organism	Sus scrofa

Kla Sites from experimental identification

Position	Flanking peptide
527	VLATRSRKLPHELCA

Function

Substrate recognition and binding subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins

Protein Sequence

10 MAPAPPRPRP 20 ESPAPVARRS 30 ATAPSLRPLL 40 PPRAAAARAR 50 TPRAGSGGRG 60 PGGGAGSDDR 70 SGGRRPKMAA 80 VVLAATRLLR 90 GSGPWGRSRL 100 RFGAPAGRQF 110 SSGGAYPNIP 120 LSSPLPGVPK 130 PVFATVDGQE 140 KFETKVTTLD 150 NGLRVASQNK 160 FGQFCTVGIL 170 INSGSRYEAK 180 YLSGIAHFLE 190 KLAFSSTDRF 200 ASKDEILLTL 210 EKHGGICDCQ 220 TSRDTTMYAV 230 SANSKGLDTV 240 VGLLADVVLH 250 PRLTDEELEM 260 TRMAVQFELE 270 DLNMRPDPEP 280 LLTEMIHQAA 290 YRENTVGLQR 300 LCPAENVAKM 310 DRAELHAYLR 320 NYYTPDRMVL 330 AAVGVEHQHL 340 VECARKHLLG 350 SRPAWGSDGA 360 VQVDRSVAQY 370 TGGIVKLERD 380 MSNVSLGPAP 390 FPELTHVMIG 400 LESCSFLEAD 410 FIPFAVLNMM 420 MGGGGSFSAG 430 GPGKGMFTRL 440 YLNVLNRHHW 450 MYNATSYHHS 460 YEDTGLLCIH 470 ASADPRQVRE 480 MVEIVTREFV 490 LMAGAVDVVE 500 LARAKTQLTS 510 MLMMNLEARP 520 VVFEDVGRQV 530 LATRSRKLPH 540 ELCALIRDVK 550 PEDIKRVASR 560 CSVASRPWPP 570 WGPWATCRRT 580 STSRRRWPAR 590 TGGCPGPTAS 600 SARARGRRRL LLRSLG

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005743	mitochondrial inner membrane
Cellular Component	GO:0017087	mitochondrial processing peptidase complex
Molecular Function	GO:0046872	metal ion binding
Molecular Function	GO:0004222	metalloendopeptidase activity
Biological Process	GO:0006627	protein processing involved in protein targeting to mitochondrion

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.