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Overview

Uniprot IDA0A286ZRZ7
Protein NameC-Jun-amino-terminal kinase-interacting protein 4
Gene NameSPAG9
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
1061 VWCGYRNKIYVVQPK
597 LSQLPGDKSKAFDFL
994 CLHSIKLKDSILSIV

Function

The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Regulates lysosomal positioning by acting as an adapter protein which links PIP4P1-positive lysosomes to the dynein-dynactin complex. Assists PIKFYVE selective functionality in microtubule-based endosome-to-TGN trafficking

Protein Sequence

10 MELEDGVVYQ 20 EEPGGSGAVM 30 SERVSGLAGS 40 IYREFERLIG 50 RYDEEVVKEL 60 MPLVVAVLEN 70 LDSVFAQDQE 80 HQVELELLRD 90 DNEQLITQYE 100 REKALRKHAE 110 EKFIEFEDSQ 120 EQEKKDLQTR 130 VESLESQTRQ 140 LELKAKNYAD 150 QISRLEEREA 160 ELKKEYNALH 170 QRHTEMIHNY 180 MEHLERTKLH 190 QLSGSDQLES 200 TAHSRIRKER 210 PISLGIFPLP 220 AGEGLLTPDT 230 QKGGETPGSE 240 QWKFQELSQP 250 RSHTSLKDEL 260 SDVSQGGSKA 270 TTPASTAASD 280 VAAIPADTPL 290 NEDNEGFVKV 300 AETPDKSEIS 310 KHIEVQVAQE 320 TRNVSIGSAE 330 NEEKSEVQAI 340 IESTPELDMD 350 KDLSGYKGSS 360 TPTKGIENKA 370 FDRNTESLFE 380 ELSSAGSGLI 390 GDVDEGADLL 400 DFYLLSLVGM 410 GREVENLILE 420 NTQLLETKNA 430 LNVVKNDLIA 440 KVDELTCEKD 450 VLQGELEAVK 460 QAKLKLEEKN 470 KELEEELRKA 480 RAEAEDARQK 490 AKDDDDSDIP 500 TAQRKRFTRV 510 EMARVLMERN 520 QYKERLMELQ 530 EAVRWTEMIR 540 ASRENPAMQE 550 KKRSSIWQFF 560 SRLFSSSSNT 570 TKKPEPPVNL 580 KYNAPTSHVT 590 PSVKKRSSTL 600 SQLPGDKSKA 610 FDFLSEETEA 620 SLASRREQKR 630 EQYRQVKAHV 640 QKEDGRVQAF 650 GWSLPQKYKQ 660 VTNGQGENKM 670 KNLPVPVYLR 680 PLDEKDASMK 690 LWCAVGVNLS 700 GGKTRDGGSV 710 VGASVFYKDV 720 AGLESEGSKQ 730 RSASQSSLDK 740 LDQELKEQQK 750 ELKNQEELSS 760 LVWICTSTHS 770 ATKVIIIDAV 780 QPGNILDSFT 790 VCNSHVLCIA 800 SVPGARETDY 810 PAGEELSESG 820 QVDKASLCGS 830 MTSNSSTETD 840 SLLGGITVVG 850 CSTEGVTAVA 860 TSPSTNGTSP 870 VTEKPPEKEA 880 ENSEVDENVP 890 TAEEATEATE 900 GNAGSAEDTV 910 DISQAGVYTE 920 HVFTDPLGVQ 930 IPEDLSPVYQ 940 SSNDSDAYKD 950 QISVLPNEQD 960 LVREEAQKMS 970 SLLPTMWLGA 980 QNGCLYVHSS 990 VAQWRKCLHS 1000 IKLKDSILSI 1010 VHVKGIVLVA 1020 LADGTLAIFH 1030 RGVDGQWDLS 1040 NYHLLDLGRP 1050 HHSIRCMTVV 1060 HDKVWCGYRN 1070 KIYVVQPKAM 1080 KIEKSFDAHP 1090 RKESQVRQLA 1100 WVGDGVWVSI 1110 RLDSTLRLYH 1120 AHTYQHLQDV 1130 DIEPYVSKML 1140 GTGKLGFSFV 1150 RITALMVSCN 1160 RLWVGTGNGV 1170 IISIPLTETV 1180 ILHQGRLLGL 1190 RANKTSGASG 1200 NRPGSVIRVY 1210 GDENSDKVTP 1220 GTFIPYCSMA 1230 HAQLCFHGHR 1240 DAVKFFVAVP 1250 GQVISPQSGS 1260 SGTDLTADKV 1270 GPSAQEPGSQ 1280 TPLKSMLVIS 1290 GGEGYIDFRM 1300 GDEGGESELL 1310 GEDLPLEPSV 1320 TKAERSHLIV WQVMYGSE

Gene Ontology

Classification GO ID Description
Cellular Component GO:0034451 centriolar satellite
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005765 lysosomal membrane
Cellular Component GO:0048471 perinuclear region of cytoplasm
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0008432 JUN kinase binding
Molecular Function GO:0019894 kinesin binding
Molecular Function GO:0005078 MAP-kinase scaffold activity
Molecular Function GO:0030159 signaling receptor complex adaptor activity
Biological Process GO:0032418 lysosome localization
Biological Process GO:0030335 positive regulation of cell migration
Biological Process GO:0016192 vesicle-mediated transport

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.