Overview
| Uniprot ID | A0A286ZS96 |
|---|
| Protein Name | Transcriptional enhancer factor TEF-4 |
|---|
| Gene Name | TEAD2 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 67 |
YPPCGRRKIILSDEG |
Function
Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3'). May be involved in the gene regulation of neural development. Binds to the M-CAT motif
Protein Sequence
10
MGEPRAGAPL
20
DDGSGWTGSE
30
EGSEEGTGGS
40
EGAGGDGGPD
50
AEGVWSPDIE
60
QSFQEALAIY
70
PPCGRRKIIL
80
SDEGKMYGRN
90
ELIARYIKLR
100
TGKTRTRKQV
110
SSHIQVLARR
120
KSREIQSKLK
130
ALNVDQVSKD
140
KAFQTMATMS
150
SAQLISAPSL
160
QAKLGPAGPQ
170
APELFQFWSG
180
GSGPPWNVPY
190
EPPQTLSPPA
200
LPPPAPSPPA
210
WQARALGTAR
220
LQLVEFSAFV
230
EPPDAADSYQ
240
RHLFVHISQH
250
CPSPGAPPLE
260
SVDVRQIYDK
270
FPEKKGGLRE
280
LYDRGPPHAF
290
FLVKFWADLN
300
WGPSGEEVGA
310
SGSSGGFYGV
320
SSQYESLEHM
330
TLTCSSKVCS
340
FGKQVVEKVE
350
TERAQLEDGR
360
FVYRLLRSPM
370
CEYLVNFLHK
380
LRQLPERYMM
390
NSVLENFTIL
400
QVVTNRDTQE
410
LLLCTAYVFE
420
VSTSERGAQH
HIYRLVRD
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Cellular Component |
GO:0005667 |
transcription regulator complex |
| Molecular Function |
GO:0003700 |
DNA-binding transcription factor activity |
| Molecular Function |
GO:1990837 |
sequence-specific double-stranded DNA binding |
| Biological Process |
GO:0006351 |
DNA-templated transcription |
| Biological Process |
GO:0035329 |
hippo signaling |
| Biological Process |
GO:0045893 |
positive regulation of DNA-templated transcription |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.