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Overview

Uniprot IDA0A286ZSH4
Protein NameFACT complex subunit SSRP1
Gene NameSSRP1
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
248 RLFLLPHKDQRQMFF
325 MKALVNRKITVPGNF
364 RGFIYVHKPPVHIRF
63 VALGHGLKLLTKNGH
90 EKLSDFFKTHYRLEL

Function

Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II

Protein Sequence

10 MAETLEFNDV 20 YQEVKGSMND 30 GRLRLSRQGI 40 IFKNSKTGKV 50 DNIQAGELTE 60 GIWRRVALGH 70 GLKLLTKNGH 80 VYKYDGFRES 90 EFEKLSDFFK 100 THYRLELMEK 110 DLCVKGWNWG 120 TVKFGGQLLS 130 FDIGDQPVFE 140 IPLSNVSQCT 150 TGKNEVTLEF 160 HQNDDAEVSL 170 MEVRFYVPPT 180 QEDGVDPVEA 190 FAQNVLSKAD 200 VIQATGDAIC 210 IFRELQCLTP 220 RGRYDIRIYP 230 TFLHLHGKTF 240 DYKIPYTTVL 250 RLFLLPHKDQ 260 RQMFFVISLD 270 PPIKQGQTRY 280 HFLILLFSKD 290 EDISLTLNMN 300 EEEVEKRFEG 310 RLTKNMSGSL 320 YEMVSRVMKA 330 LVNRKITVPG 340 NFQGHSGAQC 350 ITCSYKASSG 360 LLYPLERGFI 370 YVHKPPVHIR 380 FDEISFVNFA 390 RGTTTTRSFD 400 FEIETKQGTQ 410 YTFSSIEREE 420 YGKLFDFVNA 430 KKLNIKNRGL 440 KEGMNPSYDE 450 YADSDEDQHD 460 AYLERMKEEG 470 KIREENANDS 480 SDDSGEETDE 490 SFNPGEEEED 500 VAEEFDSNAS 510 ASSSSNEGDS 520 DRDEKKRKQL 530 KKAKMAKDRK 540 SRKKPTEVKK 550 GKDPNAPKRP 560 MSAYMLWLNA 570 SREKIKSDHP 580 GISITDLSKK 590 AGEIWKGMSK 600 EKKEEWDRKA 610 EDARREYEKA 620 MKEYEGGRGE SSKR

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005694 chromosome
Cellular Component GO:0005730 nucleolus
Molecular Function GO:0003677 DNA binding
Biological Process GO:0006281 DNA repair
Biological Process GO:0006260 DNA replication
Biological Process GO:0006351 DNA-templated transcription

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.