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Overview

Uniprot IDA0A286ZSM7
Protein NameGelsolin
Gene NameGSN
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
137 GGVASGFKHVVPNEV
153 VQRLFQVKGRRVVRA
205 LKATQVSKGIRDNER
298 CFILDHGKDGKIFVW
301 LDHGKDGKIFVWKGK
306 DGKIFVWKGKQANTE
320 EERKAALKTASDFIS
635 RLFACSNKIGRFVIE
688 TEALTSAKRYIETDP

Function

Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis

Protein Sequence

10 MEKLFCCFPS 20 TMVVEHPEFL 30 KAGKEPGLQI 40 WRVEKFDLVP 50 VPPNLYGDFF 60 TGDAYVILKT 70 VQLRNGNLQY 80 DLHYWLGNEC 90 SQDESGAAAI 100 FTVQLDDYLN 110 GRAVQHREVQ 120 GFESATFLGY 130 FKSGLKYKKG 140 GVASGFKHVV 150 PNEVAVQRLF 160 QVKGRRVVRA 170 TEVPVSWESF 180 NRGDCFILDL 190 GNDIYQWCGS 200 NSNRYERLKA 210 TQVSKGIRDN 220 ERSGRAHVHV 230 SEEDAEPAGM 240 LQVLGPKPTL 250 PEGTEDTVKE 260 DAANRKLAKL 270 YKVSNGAGTM 280 TVSLVADENP 290 FAQGALKSED 300 CFILDHGKDG 310 KIFVWKGKQA 320 NTEERKAALK 330 TASDFISKMN 340 YPKQTQVSVL 350 PEGGETPLFK 360 QFFKNWRDPD 370 QVDGPGLSYL 380 SSHIANVERV 390 PFDAATLHTS 400 TAMAAQHGMD 410 DDGTGQKQIW 420 RIEGSNKVPV 430 DPATYGQFYG 440 GDSYIILYNY 450 RHGGRQGQII 460 YNWQGAQSTQ 470 DEVAASAILT 480 AQLDEELGGT 490 PVQSRVVQGK 500 EPAHLMSLFG 510 GKPMIIYRGG 520 TSREGGQTAP 530 ASTRLFQVRA 540 SSSGATRAVE 550 VIPKAGALNS 560 NDAFVLKTPS 570 AAYLWVGTGA 580 SEAEKTGAQE 590 LLRVLRAQPV 600 QVAEGSEPDS 610 FWEALGGKAA 620 YRTSPRLKDK 630 KMDAHPPRLF 640 ACSNKIGRFV 650 IEEVPGELMQ 660 EDLATDDVML 670 LDTWDQVFVW 680 VGKDSQEEEK 690 TEALTSAKRY 700 IETDPANRDR 710 RTPINVVKQG 720 FEPPSFVGWF 730 LSWDDNYWSV 740 DPLDRAIAEL AA

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005856 cytoskeleton
Molecular Function GO:0051015 actin filament binding
Molecular Function GO:0046872 metal ion binding
Biological Process GO:0007015 actin filament organization
Biological Process GO:0051014 actin filament severing
Biological Process GO:0051016 barbed-end actin filament capping
Biological Process GO:0060271 cilium assembly

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.