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Overview

Uniprot IDA0A286ZSR3
Protein NameAcyl-coenzyme A oxidase
Gene NameACOX1
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
295 EAARCLSKACTIAIR

Function

Involved in the initial and rate-limiting step of peroxisomal beta-oxidation of straight-chain saturated and unsaturated very-long-chain fatty acids. Catalyzes the desaturation of fatty acyl-CoAs that have a saturated bond between C2 and C3 (2,3-saturated acyl-CoA) to 2-trans-enoyl-CoAs ((2E)-enoyl-CoAs), and donates electrons directly to molecular oxygen (O(2)), thereby producing hydrogen peroxide (H(2)O(2))

Protein Sequence

10 MNQDLQKERA 20 AASFNPELLT 30 HVLDGSPENT 40 RRRREIENMI 50 LSDPDLQHED 60 LNFLSRSQRY 70 EVAVKKSATT 80 VKKIREFGLA 90 DPDEILWFKK 100 LHLVNFVEPV 110 GLNYSMFIPT 120 LLSQGTTAQR 130 EKWLPPSKRL 140 EIIGTYAQTE 150 LGHGTHLRGL 160 ETTATYDPAT 170 EEFILNSPTV 180 TSIKWWPGGL 190 GKTSNHAIVL 200 AQLITQGKCY 210 GLHAFIVPIR 220 EQGTHKPLPG 230 ITVGDIGPKF 240 GYDEMDNGYL 250 KMDNYRIPRE 260 NMLMKYAQVK 270 PDGTYVKPLS 280 NKLTYGTMVF 290 IRSFLVGEAA 300 RCLSKACTIA 310 IRYSAVRHQS 320 ELRPDEPEPQ 330 ILDYQTQQYK 340 LFPFLATAYA 350 FQFVGAYIKE 360 TYHRINENIR 370 QGDLSGLPEL 380 HALTAGLKAF 390 TSWTANAAIE 400 ACRMACGGHG 410 YSHCSGLPNI 420 YVNFTPTCTF 430 EGENTVMMLQ 440 TARFLMKSYN 450 QVHSGKLVCG 460 MVSYLNDLPS 470 QRIQPQQVAA 480 WPTVADINSP 490 DSLIEAYRLR 500 ASRLVEIAAK 510 NLQTEMSHRK 520 SKEAAWNLTS 530 IDLVRASEAH 540 CHYVVVKLFA 550 EKLHQIQERS 560 IHAVLRNLCL 570 LYALYGISQN 580 SGDFLQGSIM 590 TESQVTHVNE 600 RVKELLMAIR 610 PEAVALVDAF 620 DFQDVTLGSV 630 LGRYDGNVYE 640 NMFEWAKKSP 650 LNKTEVKSKN 660 SFSPFLKSFI

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005777 peroxisome
Molecular Function GO:0003997 acyl-CoA oxidase activity
Molecular Function GO:0071949 FAD binding
Molecular Function GO:0005504 fatty acid binding
Biological Process GO:0033540 fatty acid beta-oxidation using acyl-CoA oxidase

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.