Search Results
Overview
| Uniprot ID | A0A286ZT34 |
|---|---|
| Protein Name | eIF5-mimic protein 1 |
| Gene Name | BZW2 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 386 | NAVEWNKKEELVAEQ |
Function
Translation initiation regulator which represses non-AUG initiated translation and repeat-associated non-AUG (RAN) initiated translation by acting as a competitive inhibitor of eukaryotic translation initiation factor 5 (EIF5) function. Increases the accuracy of translation initiation by impeding EIF5-dependent translation from non-AUG codons by competing with it for interaction with EIF2S2 within the 43S pre-initiation complex (PIC) in an EIF3C-binding dependent manner
Protein Sequence
10
MELACQAISA
20
WGHASPWLSL
30
HSPFHFPGRG
40
TTRTGGGLGG
50
GAAWEAGLRR
60
APCVDVNVSV
70
LHSSIVCRHH
80
YRRCHRRCRS
90
CRSPQPRASP
100
LPPRTDEKEK
110
FEPTVFRDTL
120
VQGLNEAGDD
130
LEAVAKFLDS
140
TGSRLDYRRY
150
ADTLFDILVA
160
GSMLAPGGTR
170
IDDGDKTKMT
180
NHCVFSANED
190
HETIRNYAQV
200
FNKLIRRYKY
210
LEKAFEDEMK
220
KLLLFLKAFS
230
ETEQTKLAML
240
SGILLGNGTL
250
PATILTSLFT
260
DSLVKEGIAA
270
SFAVKLFKAW
280
MAEKDANSVT
290
SSLRKANLDK
300
RLLELFPVNR
310
QSVDHFAKYF
320
TDAGLKELSD
330
FLRVQQSLGT
340
RKELQKELQE
350
RLSQECPIKE
360
VVLYVKEEMK
370
RNDLPETAVI
380
GLLWTCIMNA
390
VEWNKKEELV
400
AEQALKHLKQ
410
YAPLLAVFSS
420
QGQSELILLQ
430
KVQEYCYDNI
440
HFMKAFQKIV
450
VLFYKADVLS
460
EEAILKWYKE
470
AHVAKGKSVF
480
LDQMKKFVEW
490
LQNAEEESES
EGEEN
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Biological Process | GO:0006446 | regulation of translational initiation |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.