Search Results
Overview
| Uniprot ID | A0A286ZT83 |
|---|---|
| Protein Name | Ran-binding protein 3 |
| Gene Name | RANBP3 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 180 | SEEENCEKKEQVAQQ |
| 181 | EEENCEKKEQVAQQA |
Function
Acts as a cofactor for XPO1/CRM1-mediated nuclear export, perhaps as export complex scaffolding protein. Bound to XPO1/CRM1, stabilizes the XPO1/CRM1-cargo interaction. In the absence of Ran-bound GTP prevents binding of XPO1/CRM1 to the nuclear pore complex. Binds to CHC1/RCC1 and increases the guanine nucleotide exchange activity of CHC1/RCC1. Recruits XPO1/CRM1 to CHC1/RCC1 in a Ran-dependent manner. Negative regulator of TGF-beta signaling through interaction with the R-SMAD proteins, SMAD2 and SMAD3, and mediating their nuclear export
Protein Sequence
10
MADLANEEKP
20
AIAPPVFVFQ
30
KDKGQKRSAG
40
GSSPEGGEDS
50
DREDGNYCPP
60
VKRERTSSLT
70
QFPPSQSEEK
80
SSGFRLKPPT
90
LIHGQAPSAG
100
LPSQKPKEQQ
110
RSVLRPAVLQ
120
APQPKALSQT
130
VPSTGTNGVS
140
VPADCTGAVT
150
LASPDNPARR
160
SPSDEVPALE
170
EKESQKNESS
180
NTSEEENCEK
190
KEQVAQQAFV
200
FGQNLRDRVK
210
LINENTEVAD
220
MENAGHPSSE
230
TPTATNYFLQ
240
YISSSLENST
250
NSADAASSKF
260
IFGQNMSERV
270
LSPPKLNEVS
280
SDANRETIAA
290
ESGSESSSQE
300
ATPEKESLAE
310
SAAAYTKATA
320
RKCLLEKVEV
330
ITGEEAESNV
340
LQIQCKLFVF
350
DKTSQSWVER
360
GRGLLRLNDM
370
ASTDDGTLQS
380
RLVMRTQGSL
390
RLILNTKLWA
400
QMQIDKASEK
410
SIRITAMDTE
420
DQGVKVFLIS
430
ASSKDTGQLY
440
AALHHRILAL
450
RSRVEQEQEA
460
KTPAPEPGAA
470
PSNEDDSDDD
480
DVLAPSGATG
490
SGAGDEGDGQ
TAGST
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Biological Process | GO:0015031 | protein transport |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.