Search Results

Overview

Uniprot IDA0A286ZTB3
Protein NameCalcium-transporting ATPase
Gene NameATP2B1
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
247 TGESDHVKKSLDKDP
596 GSYRIFSKGASEIIL
64 YGICTRLKTSPVEGL
752 IEQERIDKIWPKLRV
768 ARSSPTDKHTLVKGI

Function

Catalyzes the hydrolysis of ATP coupled with the transport of calcium from the cytoplasm to the extracellular space thereby maintaining intracellular calcium homeostasis. Plays a role in blood pressure regulation through regulation of intracellular calcium concentration and nitric oxide production leading to regulation of vascular smooth muscle cells vasoconstriction. Positively regulates bone mineralization through absorption of calcium from the intestine. Plays dual roles in osteoclast differentiation and survival by regulating RANKL-induced calcium oscillations in preosteoclasts and mediating calcium extrusion in mature osteoclasts. Regulates insulin sensitivity through calcium/calmodulin signaling pathway by regulating AKT1 activation and NOS3 activation in endothelial cells. May play a role in synaptic transmission by modulating calcium and proton dynamics at the synaptic vesicles

Protein Sequence

10 MGDMANNSVA 20 YGGVKNSLKE 30 ANHDGDFGIT 40 LAELRALMEL 50 RSTDALRKIQ 60 ESYGDVYGIC 70 TRLKTSPVEG 80 LSGNPADIER 90 REAVFGKNFI 100 PPKKPKTFLQ 110 LVWEALQDVT 120 LIILEIAAIV 130 SLGLSFYQPP 140 EGDNALSVGE 150 EEGEGETGWI 160 EGAAILLSVV 170 CVVLVTAFND 180 WSKEKQFRGL 190 QSRIEQEQKF 200 TVIRGGQVIQ 210 IPVADITVGD 220 IAQVKYGDLL 230 PADGILIQGN 240 DLKIDESSLT 250 GESDHVKKSL 260 DKDPLLLSGT 270 HVMEGSGRMV 280 VTAVGINSQT 290 GIIFTLLGAG 300 GEEEEKKDEK 310 KKEKKIPGPG 320 TSICHGCTKA 330 QDGAAMEMQP 340 LKSEEGGDGD 350 EKDKKKANLP 360 KKEKSVLQGK 370 LTKLAVQIGK 380 AGLLMSAITV 390 IILVLYFVID 400 TFWVQKRPWL 410 AECTPIYIQY 420 FVKFFIIGVT 430 VLVVAVPEGL 440 PLAVTISLAY 450 SVKKMMKDNN 460 LVRHLDACET 470 MGNATAICSD 480 KTGTLTMNRM 490 TVVQAYINEK 500 HYKKIPEPEA 510 IPPNILSYLV 520 TGISVNCAYT 530 SKILPPEKEG 540 GLPRHVGNKT 550 ECALLGLLLD 560 LKRDYQDVRN 570 EIPEEALYKV 580 YTFNSVRKSM 590 STVLKNSDGS 600 YRIFSKGASE 610 IILKKCFKIL 620 SANGEAKVFR 630 PRDRDDIVKT 640 VIEPMASEGL 650 RTICLAFRDF 660 PAGEPEPEWD 670 NENDIVTGLT 680 CIAVVGIEDP 690 VRPEVPDAIK 700 KCQRAGITVR 710 MVTGDNINTA 720 RAIATKCGIL 730 HPGEDFLCLE 740 GKDFNRRIRN 750 EKGEIEQERI 760 DKIWPKLRVL 770 ARSSPTDKHT 780 LVKGIIDSTV 790 SDQRQVVAVT 800 GDGTNDGPAL 810 KKADVGFAMG 820 IAGTDVAKEA 830 SDIILTDDNF 840 TSIVKAVMWG 850 RNVYDSISKF 860 LQFQLTVNVV 870 AVIVAFTGAC 880 ITQDSPLKAV 890 QMLWVNLIMD 900 TLASLALATE 910 PPTESLLLRK 920 PYGRNKPLIS 930 RTMMKNILGH 940 AFYQLVVVFT 950 LLFAGEKFFD 960 IDSGRNAPLH 970 APPSEHYTIV 980 FNTFVLMQLF 990 NEINARKIHG 1000 ERNVFEGIFN 1010 NAIFCTIVLG 1020 TFVVQIIIVQ 1030 FGGKPFSCSE 1040 LSIEQWLWSI 1050 FLGMGTLLWG 1060 QLISTIPTSR 1070 LKFLKEAGHG 1080 TQKEEIPEEE 1090 LAEDVEEIDH 1100 AERELRRGQI 1110 LWFRGLNRIQ 1120 TQIRVVNAFR 1130 SSLYEGLEKP 1140 ESRSSIHNFM 1150 THPEFRIEDS 1160 EPHIPLIDDT 1170 DAEDDAPTKR 1180 NCSPPPSPNK 1190 NNNAVDSGIY 1200 LTIEMNKSAT 1210 SSSPGSPLHS LETSL

Gene Ontology

Classification GO ID Description
Cellular Component GO:0042734 presynaptic membrane
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0016887 ATP hydrolysis activity
Molecular Function GO:0005516 calmodulin binding
Molecular Function GO:0046872 metal ion binding
Molecular Function GO:0005388 P-type calcium transporter activity
Cellular Component GO:0030672 synaptic vesicle membrane

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.