Search Results

Overview

Uniprot ID	A0A286ZTD6
Protein Name	CLIP-associating protein 1
Gene Name	CLASP1
Organism	Sus scrofa

Kla Sites from experimental identification

Position	Flanking peptide
456	ITSNCTSKSVAVRRR

Function

Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle

Protein Sequence

10 MEPRMEACLA 20 QVLQKDVGKR 30 LQVGQELIDY 40 FSDKQKSADL 50 EHDQTMLDKL 60 VDGLATSWVN 70 SSNYKVALLG 80 MDILSALVTR 90 LQDRFKAQIG 100 TVLPSLIDRL 110 GDAKDSVREQ 120 DQTLLLKIMD 130 QAANPQYVWD 140 RMLGGFKHKN 150 FRTREGTCLC 160 LVATLNASGA 170 HTLTLSKIVP 180 HICNLLGDPN 190 SQVRDAAINS 200 LVEIYRHVGE 210 RVRADLSKKG 220 LPQSRLNVIF 230 TKFDEVQKSG 240 NMVQSANDKN 250 FDDEDSVDGN 260 RPSSASSTSS 270 KAPPSSRRNV 280 GMGTTRRLGS 290 STVGSKSSAA 300 KEGAGAVDEE 310 DFIKAFDDVP 320 VVQIYSSRDL 330 EESINKIREI 340 LSDDKHDWEQ 350 RVNALKKIRS 360 LLLAGAAEYD 370 NFFQHLRLLD 380 GAFKLSAKDL 390 RSQVVREACI 400 TLGHLSSVLG 410 NKFDHGAEAI 420 MPTIFNLIPN 430 SAKIMATSGV 440 VAVRLIIRHT 450 HIPRLIPVIT 460 SNCTSKSVAV 470 RRRCFEFLDL 480 LLQEWQTHSL 490 ERHISVLAET 500 IKKGIHDADS 510 EARIEARKCY 520 WGFHSHFSRE 530 AEHLYHTLES 540 SYQKALQSHL 550 KNSDSIASLP 560 QSDRSSSSSQ 570 ESLNRPLSAK 580 RSPTGSTTSR 590 ASTVSTKSVS 600 TTGSLQRSRS 610 DIDVNAAASA 620 KSKVTSTPGT 630 TPFSSAAALP 640 PGSYASLGRI 650 RTRRQSSGSA 660 TNVASTPSDS 670 RGRSRAKVVS 680 QSQRSRSANP 690 AGAGSRSSSP 700 GKLLGSGYSG 710 LAGSSSRGPP 720 VTPSSEKRSK 730 IPRSQGCSRE 740 TSPSRIGLAR 750 SSRIPRPSMS 760 QGCSRDTSRE 770 SSRDTSPARG 780 FPPLDRFGLG 790 QAGRIPGSVN 800 AMRVLSTSTD 810 LEAAVADALK 820 KPVRRRYEPY 830 GMYSDDDANS 840 DASSVCSERS 850 YGSRNGGIPH 860 YLRQTEDVAE 870 VLNHCASSNW 880 SERKEGLLGL 890 QNLLKSQRTL 900 SRVELKRLCE 910 IFTRMFADPH 920 SKVFSMFLET 930 LVDFIIIHKD 940 DLQDWLFVLL 950 TQLLKKMGAD 960 LLGSVQAKVQ 970 KALDVTRDSF 980 PFDQQFNILM 990 RFIVDQTQTP 1000 NLKVKVAILK 1010 YIESLARQMD 1020 PTDFVNSSET 1030 RLAVSRIITW 1040 TTEPKSSDVR 1050 KAAQIVLISL 1060 FELNTPEFTM 1070 LLGALPKTFQ 1080 DGATKLLHNH 1090 LKNSSNTSVG 1100 SPSNTIGRTP 1110 SRHTSSRTSP 1120 LTSPTNCSHG 1130 GLSPSRLWGW 1140 SADGLSKHPP 1150 PFSQPNSIPT 1160 APSHKTLRRS 1170 YSPSMLDYDT 1180 ENLNSEEIYS 1190 SLRGVTEAIE 1200 KFSFRSQEDL 1210 NEPIKRDGRK 1220 DCEIVPRDGG 1230 VASPATEGRG 1240 GSDVVAGGRT 1250 ALDNKTSLLN 1260 TQPPRAFPGP 1270 RARDYSPYPY 1280 CDAISAYDKT 1290 ALQEAVFDDD 1300 MEQLRDVPID 1310 HSDLVADLLK 1320 ELSNHNERVE 1330 ERKGALLELL 1340 KVTREDSLGV 1350 WEEHFKTILL 1360 LLLETLGDKD 1370 HSIRALALRV 1380 LREILRNQPA 1390 RFKNYAELTI 1400 MKTLEAHKDS 1410 HKEVVRAAEE 1420 AASTLASSIH 1430 PEQCIKVLCP 1440 IIQTADYPIN 1450 LAAIKMQTKV 1460 VERIAKESLL 1470 QLLADIIPGL 1480 LQGYDNTESS 1490 VRKASVFCLV 1500 AIYSVIGEEL 1510 KPHLAQLTGS 1520 KMKLLNLYIK 1530 RAQTTNSNSS SSSDVSTHS

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005813	centrosome
Cellular Component	GO:0005794	Golgi apparatus
Cellular Component	GO:0000776	kinetochore
Cellular Component	GO:0005874	microtubule
Cellular Component	GO:0005819	spindle
Molecular Function	GO:0008017	microtubule binding
Biological Process	GO:0051301	cell division
Biological Process	GO:0030010	establishment of cell polarity
Biological Process	GO:0007026	negative regulation of microtubule depolymerization

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.