Overview
| Uniprot ID | A0A286ZTD7 |
|---|
| Protein Name | Cleavage and polyadenylation specificity factor subunit 7 |
|---|
| Gene Name | CPSF7 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 388 |
RVLISSLKDCLHGIE |
Function
Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs. CPSF7 activates directly the mRNA 3'-processing machinery. Binds to pA signals in RNA substrates
Protein Sequence
10
MSEGVDLIDI
20
YADEEFNQDP
30
EFNNTDQIDL
40
YDDVLTATSQ
50
PSDDRSSSTE
60
PPPPVRQEPS
70
PKPNNKTPAI
80
LYTYSGLRNR
90
RAAVYVGSFS
100
WWTTDQQLIQ
110
VIRSIGVYDV
120
VELKFAENRA
130
NGQSKGYAEV
140
VVASENSVHK
150
LLELLPGKVL
160
NGEKVDVRPA
170
TRQNLSQFEA
180
QARKRIPPRA
190
HSRDSSDSAD
200
GRATPSENLV
210
PSSARVDKPP
220
SVLPYFNRPP
230
SALPLMGLPP
240
PPIPPPPPLS
250
SSFGVPPPPP
260
GIHYQHLMPP
270
PPRLPPHLAV
280
PPPGAIPPAL
290
HLNPAFFPPP
300
NATVGPPPDT
310
YMKASTPYNH
320
HGSRDSGPPP
330
STVSEAEFEE
340
IMKRNRAISS
350
SAISKAVSGA
360
SAGDYSDAIE
370
TLLTAIAVIK
380
QSRVANDERC
390
RVLISSLKDC
400
LHGIEAKSYS
410
VGASGSSSRK
420
RHRSRERSPS
430
RSRESSRRHR
440
DLLHNEDRHD
450
DYFQERNREH
460
ERHRDRERDR
HH
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005634 |
nucleus |
| Molecular Function |
GO:0003723 |
RNA binding |
| Biological Process |
GO:0006397 |
mRNA processing |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.