Search Results
Overview
| Uniprot ID | A0A286ZTE6 |
|---|---|
| Protein Name | Amyloid-beta A4 protein |
| Gene Name | APP |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 106 | KRSRKQCKTHTHIVI |
| 134 | LLVPDKCKFLHQERM |
| 60 | ESDPSGTKTCIGTKE |
Function
Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis
Protein Sequence
10
MLPGLALVLL
20
AAWTARALEV
30
PTDGNAGLLA
40
EPQVAMFCGK
50
LNMHMNVQNG
60
KWESDPSGTK
70
TCIGTKEGIL
80
QYCQEVYPEL
90
QITNVVEANQ
100
PVTIQNWCKR
110
SRKQCKTHTH
120
IVIPYRCLVG
130
EFVSDALLVP
140
DKCKFLHQER
150
MDVCETHLHW
160
HTVAKETCSE
170
KSTNLHDYGM
180
LLPCGIDKFR
190
GVEFVCCPLA
200
EESDNIDSAD
210
AEEDDSDVWW
220
GGADTDYADG
230
SEDKVVEVAE
240
EEEVADVEEE
250
EAEDDEDDED
260
GDEVEEEAEE
270
PYEEATERTT
280
SIATTTTTTT
290
ESVEEVVREV
300
CSEQAETGPC
310
RAMISRWYFD
320
VTEGKCAPFF
330
YGGCGGNRNN
340
FDTEEYCMAV
350
CGSVMSQSLL
360
KTTQEHLPQD
370
PVKLPTTAAS
380
TPDAVDKYLE
390
TPGDENEHAH
400
FQKAKERLEA
410
KHRERMSQVM
420
REWEEAERQA
430
KNLPKADKKA
440
VIQHFQEKVE
450
SLEQEAANER
460
QQLVETHMAR
470
VEAMLNDRRR
480
LALENYITAL
490
QAVPPRPRHV
500
FNMLKKYVRA
510
EQKDRQHTLK
520
HFEHVRMVDP
530
KKAAQIRSQV
540
MTHLRVIYER
550
MNQSLSLLYN
560
VPAVAEEIQD
570
EVDELLQKEQ
580
NYSDDVLANM
590
ISEPRISYGN
600
DALMPSLTET
610
KTTVELLPVN
620
GEFSLDDLQP
630
WHPFGVDSVP
640
ANTENEGSGL
650
TNIKTEEISE
660
VKMDAEFRHD
670
SGYEVHHQKL
680
VFFAEDVGSN
690
KGAIIGLMVG
700
GVVIATVIVI
710
TLVMLKKKQY
720
TSIHHGVVEV
730
DAAVTPEERH
740
LSKMQQNGYE
750
NPTYKFFEQM
QN
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0106003 | amyloid-beta complex |
| Biological Process | GO:0032722 | positive regulation of chemokine production |
| Biological Process | GO:0070374 | positive regulation of ERK1 and ERK2 cascade |
| Biological Process | GO:0045821 | positive regulation of glycolytic process |
| Biological Process | GO:0050729 | positive regulation of inflammatory response |
| Biological Process | GO:0032731 | positive regulation of interleukin-1 beta production |
| Biological Process | GO:0032755 | positive regulation of interleukin-6 production |
| Biological Process | GO:0046330 | positive regulation of JNK cascade |
| Biological Process | GO:1900273 | positive regulation of long-term synaptic potentiation |
| Biological Process | GO:1901224 | positive regulation of non-canonical NF-kappaB signal transduction |
| Biological Process | GO:0032224 | positive regulation of synaptic transmission, cholinergic |
| Biological Process | GO:2000406 | positive regulation of T cell migration |
| Biological Process | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| Biological Process | GO:0032760 | positive regulation of tumor necrosis factor production |
| Biological Process | GO:0048169 | regulation of long-term neuronal synaptic plasticity |
| Biological Process | GO:1905606 | regulation of presynapse assembly |
| Biological Process | GO:0150003 | regulation of spontaneous synaptic transmission |
| Biological Process | GO:0050808 | synapse organization |
| Cellular Component | GO:0009986 | cell surface |
| Cellular Component | GO:0005905 | clathrin-coated pit |
| Cellular Component | GO:0043198 | dendritic shaft |
| Cellular Component | GO:0043197 | dendritic spine |
| Cellular Component | GO:0005769 | early endosome |
| Cellular Component | GO:0031901 | early endosome membrane |
| Cellular Component | GO:0005783 | endoplasmic reticulum |
| Cellular Component | GO:0005615 | extracellular space |
| Cellular Component | GO:0005794 | Golgi apparatus |
| Cellular Component | GO:0005798 | Golgi-associated vesicle |
| Cellular Component | GO:0030426 | growth cone |
| Cellular Component | GO:0045121 | membrane raft |
| Cellular Component | GO:0005641 | nuclear envelope lumen |
| Cellular Component | GO:0043204 | perikaryon |
| Cellular Component | GO:0048471 | perinuclear region of cytoplasm |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0043235 | receptor complex |
| Cellular Component | GO:0099503 | secretory vesicle |
| Molecular Function | GO:0008201 | heparin binding |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0120283 | protein serine/threonine kinase binding |
| Molecular Function | GO:0051425 | PTB domain binding |
| Molecular Function | GO:0048018 | receptor ligand activity |
| Molecular Function | GO:0004867 | serine-type endopeptidase inhibitor activity |
| Molecular Function | GO:0030546 | signaling receptor activator activity |
| Molecular Function | GO:0005102 | signaling receptor binding |
| Molecular Function | GO:0046914 | transition metal ion binding |
| Biological Process | GO:1990000 | amyloid fibril formation |
| Biological Process | GO:0006915 | apoptotic process |
| Biological Process | GO:0002265 | astrocyte activation involved in immune response |
| Biological Process | GO:0007409 | axonogenesis |
| Biological Process | GO:0007155 | cell adhesion |
| Biological Process | GO:1904646 | cellular response to amyloid-beta |
| Biological Process | GO:0007417 | central nervous system development |
| Biological Process | GO:0006897 | endocytosis |
| Biological Process | GO:0007612 | learning |
| Biological Process | GO:0014005 | microglia development |
| Biological Process | GO:0001774 | microglial cell activation |
| Biological Process | GO:0098815 | modulation of excitatory postsynaptic potential |
| Biological Process | GO:0008285 | negative regulation of cell population proliferation |
| Biological Process | GO:0010629 | negative regulation of gene expression |
| Biological Process | GO:1900272 | negative regulation of long-term synaptic potentiation |
| Biological Process | GO:1990535 | neuron projection maintenance |
| Biological Process | GO:0007219 | Notch signaling pathway |
| Biological Process | GO:1905908 | positive regulation of amyloid fibril formation |
| Biological Process | GO:0050850 | positive regulation of calcium-mediated signaling |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.