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Overview

Uniprot ID	A0A286ZU66
Protein Name	ATP-dependent 6-phosphofructokinase
Gene Name	PFKM
Organism	Sus scrofa

Kla Sites from experimental identification

Position	Flanking peptide
647	FDRNFATKMGAKAMN

Function

Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis

Protein Sequence

10 MTHEEHHAAK 20 SLGVGKAIAV 30 LTSGGDAQGM 40 NAAVRAVVRV 50 GIYTGARVFF 60 VHEGYQGLVD 70 GGDNIREATW 80 ESVSMMLQLG 90 GTVIGSARCK 100 DFREREGRLR 110 AAHNLVKRGI 120 TNLCVIGGDG 130 SLTGADTFRS 140 EWGDLLNDLQ 150 KAGKITAEEA 160 NKSSYLNIVG 170 LVGSIDNDFC 180 GTDMTIGTDS 190 ALHRIIEIVD 200 AITTTAQSHQ 210 RTFVLEVMGR 220 HCGYLALVTS 230 LSCGADWVFI 240 PECPPDDAWE 250 EHLCRRLSET 260 RTRGSRLNII 270 IVAEGAIDKN 280 GQPITSENIK 290 DGSRMGVEAV 300 MALLEGTPDT 310 PACVVSLSGN 320 QAVRLPLMEC 330 VQVTKDVTKA 340 MNEKRFDEAM 350 KLRGRSFMNN 360 WEVYKLLAHV 370 RPPVTKSGSY 380 TVAVMNVGAP 390 AAGMNAAVRS 400 TVRIGLIQGN 410 RVLVVHDGFE 420 GLAKGQIEEA 430 GWSYVGGWTG 440 QGGSKLGTKR 450 TLPKKSFEQI 460 SANITKFNIQ 470 GLVIIGGFEA 480 YTGGLELMEG 490 RKQYDELCIP 500 FVVIPATVSN 510 NVPGSDFSVG 520 ADTALNTICM 530 TCDRIKQSAA 540 GTKRRVFIIE 550 TMGGYCGYLA 560 TMAGLAAGAD 570 AAYIFEEPFT 580 IRDLQVNVEH 590 LVQKMKTTVK 600 RGLVLRNEKC 610 NENYTTDFIF 620 NLYSEEGKGI 630 FDSRKNVLGH 640 MQQGGSPTPF 650 DRNFATKMGA 660 KAMNWMSGKI 670 KESYRNGRIF 680 ANTPDSGCVL 690 GMRKRALVFQ 700 PVTELKEQTD 710 FEHRIPKEQW 720 WLKLRPILKI 730 LAKYEIDLDT 740 SEHAHLEHIT RKRSGEATI

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005737	cytoplasm
Molecular Function	GO:0003872	6-phosphofructokinase activity
Molecular Function	GO:0005524	ATP binding
Molecular Function	GO:0046872	metal ion binding
Biological Process	GO:0006002	fructose 6-phosphate metabolic process

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.